AI Article Synopsis
- There's a need for artificial liver support to help patients until their liver heals or a donor is found.
- Selective plasma filtration is a new technique that purifies blood, aiming to lower toxins that harm the liver and kidneys, as well as inflammatory substances.
- Preclinical studies on pigs with severe liver failure show this treatment is safe and effective, significantly reducing harmful substances in the blood and improving survival rates.
Article Abstract
There is a need to develop artificial means of liver replacement and/or assistance with the aim of either supporting patients with borderline functional liver cell mass until their liver regenerates, or until a donor liver becomes available for transplantation. Selective plasma filtration is a novel approach to blood purification therapy designed to reduce the level of circulating toxins of hepatic and renal failure, mediators of inflammation and inhibitors of hepatic regeneration. The results of preclinical studies indicate that treatment of pigs with experimentally-induced fulminant hepatic failure is safe and effective in extending survival time and arresting brain swelling. In addition, the amount of ammonia, aromatic amino acids, IL6, TNFalpha and C3a removed during the 6-h treatment in the present study was higher by 34% to 175% than the total plasma content of those substances at the start of therapy.
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| http://dx.doi.org/10.1111/j.1744-9987.2006.00355.x | DOI Listing |
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