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Chemical characterization of Siraitia grosvenorii granules and their efficacy and mechanism of action on PM2.5-induced acute lung injury.
Ecotoxicol Environ Saf
January 2025
College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address:
This study aimed to investigate the potential protective properties of a traditional Chinese medicine (TCM) herbal product, Siraitia grosvenorii granules (SGG) against PM2.5-induced lung injury, as well as their active constituents and underlying mechanisms. The chemical composition of SGG, such as wogonin (MOL000173), luteolin (MOL000006), nobiletin (MOL005828), naringenin (MOL004328), acacetin (MOL001689), were identified via ultra-high-performance liquid chromatography-Q Exactive (UHPLC-QE) Orbitrap/MS.
View Article and Find Full Text PDFSingle-cell transcriptome analysis reveals cellular reprogramming and changes of immune cell subsets following tetramethylpyrazine treatment in LPS-induced acute lung injury.
PeerJ
January 2025
Department of Emergency Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Background: Acute lung injury (ALI) is a disordered pulmonary disease characterized by acute respiratory insufficiency with tachypnea, cyanosis refractory to oxygen and diffuse alveolar infiltrates. Despite increased research into ALI, current clinical treatments lack effectiveness. Tetramethylpyrazine (TMP) has shown potential in ALI treatment, and understanding its effects on the pulmonary microenvironment and its underlying mechanisms is imperative.
View Article and Find Full Text PDFUnveiling the physicochemical, photocatalytic, antibacterial and antioxidant properties of MWCNT-modified AgO/CuO/ZnO nanocomposites.
RSC Adv
January 2025
School of Material Science and Engineering, Nanjing Tech University P. R China.
Water pollution, oxidative stress and the emergence of multidrug-resistant bacterial strains are significant global threats that require urgent attention to protect human health. Nanocomposites that combine multiple metal oxides with carbon-based materials have garnered significant attention due to their synergistic physicochemical properties and versatile applications in both environmental and biomedical fields. In this context, the present study was aimed at synthesizing a ternary metal-oxide nanocomposite consisting of silver oxide, copper oxide, and zinc oxide (ACZ-NC), along with a multi-walled carbon nanotubes modified ternary metal-oxide nanocomposite (MWCNTs@ACZ-NC).
View Article and Find Full Text PDFPhellodendrine inhibits oxidative stress and promotes autophagy by regulating the AMPK/mTOR pathway in burn sepsis-induced intestinal injury.
Toxicol Res (Camb)
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Department of General Practice, Yijishan Hospital, First Affiliated Hospital of Wannan Medical College, Jinghu District, Wuhu, Anhui Province 241000, China.
Intestinal injury is an important complication of burn sepsis with limited therapeutic choices. Phellodendrine is a promising compound for gastrointestinal inflammatory diseases and is extracted from the traditional Chinese medicine phellodendron bark. The study aimed to explore the role of phellodendrine against oxidative stress and autophagy in burn sepsis-induced intestinal injury.
View Article and Find Full Text PDFHalophyte-based crop managements induce biochemical, metabolomic and proteomic changes in tomato plants under saline conditions.
Physiol Plant
January 2025
Department of Plant Breeding, CEBAS-CSIC, Group of Fruit Biotechnology, Murcia, Spain.
Halophytes display distinctive physiological mechanisms that enable their survival and growth under extreme saline conditions. This makes them potential candidates for their use in saline agriculture. In this research, tomato (Solanum lycopersium Mill.
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