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Antibacterial mechanism of lysine against Escherichia coli O157:H7, its action on lettuce and in reducing the severity of murine colitis.
Food Microbiol
August 2025
College of Food Science and Engineering, Northwest A&F University, 22 Xinong Road, Yangling, 712100, Shaanxi, China. Electronic address:
The aim of the present study was to evaluate the mechanism of antimicrobial action of Lysine (Lys) against Escherichia coli (E. coli) O157:H7. Lys alters the permeability and morphology of bacterial cell membranes, leading to leakage of intracellular material.
View Article and Find Full Text PDFFerroptosis-Related Genes Are Effective Markers for Diagnostic Targets of Crohn's Disease.
Immun Inflamm Dis
March 2025
The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
Introduction: Crohn's disease (CD) is a group of chronic transmural inflammation of gastrointestinal tract, which seriously harms the mental and physical health of adolescents. At present, there are still no specific markers that make the diagnosis of CD extremely difficult and poor prognosis. Iron deficiency is common in CD, yet the role of ferroptosis-related genes in CD has not been elucidated.
View Article and Find Full Text PDFDrug-induced enterocolitis syndrome in children: report of two cases and a literature review.
Turk J Pediatr
February 2025
Department of Pediatric Immunology and Allergy, Dr. Sami Ulus Maternity Child Health and Diseases Training and Research Hospital, Ankara, Türkiye.
Background: Drug-induced enterocolitis syndrome (DIES) is a recently defined clinical entity, first described in 2014. DIES is a hypersensitivity reaction with non-IgE mechanisms involving the gastrointestinal tract, occurring 1 to 4 hours after drug ingestion. Antibiotics are most commonly responsible, particularly amoxicillin or amoxicillin / clavulanic acid (AMX/CL).
View Article and Find Full Text PDFPlatelet activation stimulates macrophages to enhance ulcerative colitis through PF4/CXCR3 signaling.
Int J Mol Med
May 2025
Graduate School, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.
Platelets are involved in hemostasis and immune regulation, but little is currently known regarding their role in inflammatory bowel disease. In the present study, the mechanism by which platelet activation affects macrophage C‑X‑C motif chemokine receptor 3 (CXCR3) by releasing platelet factor 4 (PF4), thus aggravating ulcerative colitis (UC) disease progression, was investigated. A dextran sulfate sodium‑induced mouse model showed co‑localization of the platelet marker PF4 with the macrophage M1 marker inducible nitric oxide synthase.
View Article and Find Full Text PDFFaecal Cytolysin is Associated With Worse Survival in Patients With Primary Sclerosing Cholangitis.
Liver Int
April 2025
Department of Medicine, University of California San Diego, La Jolla, California, USA.
Background And Aims: Primary sclerosing cholangitis (PSC) is an immune-related cholangiopathy without treatment options beyond liver transplantation. The gut-liver axis, especially the role of gut microbes, has emerged as a crucial pathway contributing to PSC pathogenesis. Recent research has revealed Enterococcus (E.
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