Objectives: To report two cases of isolated corneal intraepithelial neoplasia.
Material And Method: The present study included 2 cases presenting with isolated corneal intraepithelial neoplasia. Both patients were treated by corneal epithelial scraping.
Results: The authors present the clinical picture and histopathological findings of 2 patients suffering from corneal intraepithelial neoplasia that did not arise from the corneoscleral limbus. Both patients showed no recurrence after treatment for a period of time.
Conclusion: Isolated corneal intraepithelial neoplasia is rare. Corneal scraping may be an effective treatment.
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Cornea
October 2024
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL.
Purpose: The purpose of this study was to report the management of chemoimmunotherapy-resistant ocular surface squamous neoplasia (OSSN) with iodine-125 (I-125) brachytherapy.
Methods: A 36-year-old man presented to the clinic with biopsy-proven OSSN that covered ∼70% of the corneal surface and extended to the 6 o'clock position of the inferior limbus of the OS. The visual acuity was 20/20 in the OD and 20/40 in the affected OS.
J Fr Ophtalmol
December 2024
Cornea and Refractive Surgery Department, Asociación para Evitar la Ceguera en México, I.A.P., Mexico City, Mexico.
Purpose: To evaluate the clinical outcomes of topical 5-fluorouracil (5-FU) 1% as first-line therapy for giant ocular surface squamous neoplasia (OSSN).
Materials And Methods: This was a non-comparative cohort study. We included patients with biopsy-proven giant OSSN in a tertiary-care setting.
Invest Ophthalmol Vis Sci
November 2024
Department of Anatomy and Cell Biology, GW School of Medicine and Health Sciences, Washington, District of Columbia, United States.
Purpose: The intraepithelial corneal nerves (ICNs) innervating the cornea are essential to corneal epithelial cell homeostasis. Rho-associated kinase (ROCK) inhibitors (RIs) have been reported to play roles in neuron survival after injury and in mitochondrial transfer between corneal epithelial cells. In this study, the mechanisms human corneal limbal epithelial (HCLE) cells use to control intercellular mitochondrial transfer are assessed.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
November 2024
Department of Microbiology & Immunology, University of South Alabama, Mobile, Alabama, United States.
Invest Ophthalmol Vis Sci
October 2024
Department of Anatomy and Cell Biology, GW School of Medicine and Health Sciences, Washington DC, United States.
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