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Plasmodium falciparum surf4.1 in clinical isolates: From genetic variation and variant diversity to in silico design immunopeptides for vaccine development.
PLoS One
January 2025
Department of Parasitology and Entomology, Faculty of Public Health, Mahidol University, Bangkok, Thailand.
SURFINs protein family expressed on surface of both infected red blood cell and merozoite surface making them as interesting vaccine candidate for erythrocytic stage of malaria infection. In this study, we analyze genetic variation of Pfsurf4.1 gene, copy number variation, and frequency of SURFIN4.
View Article and Find Full Text PDFImmunoinformatic approach to design T cell epitope-based chimeric vaccine targeting multiple serotypes of dengue virus.
J Biomol Struct Dyn
November 2024
Amity Institute of Virology & Immunology, Amity University Uttar Pradesh, Noida, India.
The global dengue outbreak is a significant public health concern, with the World Health Organization recording over 3 million cases and a 0.04% case fatality rate until July 2023. The infection rate is anticipated to rise in vulnerable regions worldwide.
View Article and Find Full Text PDFAn Immunoinformatic Approach for Identifying and Designing Conserved Multi-Epitope Vaccines for Coronaviruses.
Biomedicines
November 2024
Center for Toxicology and Health Risk Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.
Background/objectives: The COVID-19 pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has exposed the vulnerabilities and unpreparedness of the global healthcare system in dealing with emerging zoonoses. In the past two decades, coronaviruses (CoV) have been responsible for three major viral outbreaks, and the likelihood of future outbreaks caused by these viruses is high and nearly inevitable. Therefore, effective prophylactic universal vaccines targeting multiple circulating and emerging coronavirus strains are warranted.
View Article and Find Full Text PDFDesigning a novel multi-epitope antigen for diagnosing human cytomegalovirus infection: An immunoinformatics approach.
Biotechnol Appl Biochem
October 2024
Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Shiraz, Iran.
Article Synopsis
- Human cytomegalovirus (HCMV) can cause severe health issues, especially in those with weakened immune systems, and current diagnostic tests for HCMV have limitations in sensitivity and specificity.
- Researchers aimed to create a new, more accurate multi-epitope antigen for diagnosing HCMV infections using immunoinformatic methods, selecting five key proteins based on their antigenic properties.
- The designed antigen showed promising stability and antigenicity without cross-reactivity and is a potential candidate for better HCMV diagnosis, although further lab testing is needed to confirm its effectiveness.*
Allergies to Allergens from Cats and Dogs: A Review and Update on Sources, Pathogenesis, and Strategies.
Int J Mol Sci
September 2024
Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Inhalation allergies caused by cats and dogs can lead to a range of discomforting symptoms, such as rhinitis and asthma, in humans. With the increasing popularity of and care provided to these companion animals, the allergens they produce pose a growing threat to susceptible patients' health. Allergens from cats and dogs have emerged as significant risk factors for triggering asthma and allergic rhinitis worldwide; however, there remains a lack of systematic measures aimed at assisting individuals in recognizing and preventing allergies caused by these animals.
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