To determine the impact of multiple micromanipulation procedures for preimplantation genetic diagnosis (PGD) on embryo development, a retrospective analysis was performed of 9,925 embryos (862 PGD cycles), which were compared with 28,126 nonbiopsied embryos (2,751 consecutive intracytoplasmic sperm injection [ICSI] cycles) from the same time period. Because fertilization rates, the proportion of embryos with > or = 6 cells on day 3, and blastocyst rates were similar in the PGD and control groups, we conclude that multiple micromanipulations on oocytes and embryos can be performed safely for PGD.
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http://dx.doi.org/10.1016/j.fertnstert.2005.11.059 | DOI Listing |
AAPS PharmSciTech
January 2025
School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, Georgia, 30332-0100, U.S.A..
Delivery of therapies into skin is attractive for medical indications including vaccination and treatment of dermatoses but is highly constrained by the stratum corneum barrier. Microneedle (MN) patches have emerged as a promising technology to enable non-invasive, intuitive, and low-cost skin delivery. When combined with biodegradable polymer formulations, MN patches can further enable controlled-release drug delivery without injection.
View Article and Find Full Text PDFMethods Mol Biol
December 2024
State Key Laboratory of Virology, School of Public Health, Wuhan University, Wuhan City, Hubei Province, China.
Many members in the class Bunyaviricetes are tick-borne viruses. Experimental viral infection of ticks is greatly needed to better understand the tick-virus interactions. To date, multiple laboratory techniques for the viral infection of ticks have been documented.
View Article and Find Full Text PDFNeurosurg Rev
December 2024
Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mirror aneurysms are rare and pose therapeutic challenges, with both endovascular and microsurgical options available. Single-stage and two-stage procedures are employed, but the optimal strategy remains unclear. This systematic review and meta-analysis evaluate the efficacy and safety of different therapeutic strategies for managing mirror aneurysms.
View Article and Find Full Text PDFHeliyon
October 2024
Department of Restorative Dentistry, Faculty of Dentistry, Atatürk University, TR-25240, Erzurum, Turkey.
Objective: This clinical study aimed to assess the impact of utilizing loupes and dental operating microscopes (DOM) with varying magnifications on the success of class II direct composite restorations.
Methods: A total of 130 class II, moderately deep caries teeth from 85 patients were randomly assigned to four groups: naked eye, ×3 loupe, ×5 loupe, and ×8.5 DOM.
Nanophotonics
December 2023
State Key Laboratory of Transient Optics and Photonics, Xi'an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi'an 710119, China.
Optical vortices (OVs), as eigenmodes of optical orbital angular momentum, have been widely used in particle micro-manipulation. Recently, perfect optical vortices (POVs), a subclass of OVs, are gaining increasing interest and becoming an indispensable tool in optical trapping due to their unique property of topological charge-independent vortex radius. Here, we expand the concept of POVs by proposing concentric ring optical traps (CROTs) and apply them to trapping and rotating particles.
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