Introduction: The aim of this study was to assess the efficacy of arginine-vasopressin (AVP) as a rescue therapy in catecholamine-refractory septic and non-septic shock in extremely low birth weight (ELBW) infants with acute renal injury.
Methods: Prospective assessment of AVP therapy in three ELBW infants with catecholamine-refractory septic shock and acute renal injury (mean birth weight 600 +/- 30 g) and three ELBW infants with non-septic shock and acute renal injury (mean birth weight 770 +/- 110 g) at a University hospital. The main outcome measures were restoration of blood pressure with adequate organ perfusion and survival at discharge.
Results: In all three ELBW infants with catecholamine-resistant septic shock, systemic arterial blood pressure increased substantively with restoration of urine output after AVP administration (dosage, 0.035 to 0.36 U/kg/h; length, 70 +/- 21 hours). In the three ELBW infants with non-septic shock, only a transient stabilization in mean arterial pressure with restoration of urine output was observed after AVP therapy (dosage, 0.01 to 0.36 U/kg/h; length, 30 +/- 16 hours). The mortality rate was 1/3 in the sepsis group versus 3/3 in the non-septic group.
Conclusion: AVP may be a promising rescue therapy in catecholamine-resistant shock in ELBW infants with acute renal injury. Larger prospective clinical trials are warranted to assess the efficacy and safety of AVP as a pressor adjunct in septic versus non-septic shock in ELBW infants.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550969 | PMC |
| http://dx.doi.org/10.1186/cc4917 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association between body mass index at birth and neonatal health outcomes in preterm infants: A retrospective analysis.
Pediatr Obes
January 2025
Department of Neonatology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Background: Studies on how birth body mass index (BMI) affects health outcomes in preterm infants are relatively limited.
Aim: To analyze the association between BMI at birth and neonatal health outcomes in extremely low and very low birth weight preterm infants in China.
Methods: Used data from the Chinese Premature Infant Informatization Platform (2022-2023).
Bioelectrical Impedance Vector Analysis in Extremely Low-Birth-Weight Infants to Assess Nutritional Status: Breakthroughs and Insights.
Nutrients
December 2024
Aladina-MGU-Regional Human Milk Bank, 12 de Octubre University Hospital, 28041 Madrid, Spain.
: To obtain bioelectrical data to assess nutritional status for extremely low-birth-weight (ELBW) infants upon reaching term-corrected age. : A descriptive, observational, prospective, and single-center study, which included ELBW preterm infants was performed. The study variables collected were gestational age, sex, and anthropometry at birth and at term-corrected age.
View Article and Find Full Text PDFPost-discharge family resilience in premature infants and their mothers: A longitudinal study.
Nurs Crit Care
January 2025
Collegel of Nursing, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Article Synopsis
- Very low birth weight (VLBW) infants create significant caregiving challenges for families, making family resilience essential for managing stress and adapting after discharge.
- The study aimed to assess how family resilience affects mothers of VLBW and extremely low birth weight (ELBW) infants, focusing on aspects like social support, family functioning, and parenting stress over 3 and 6 months.
- Results showed that mothers reported moderate-to-high family resilience levels, with social support and parenting stress being strong indicators of resilience, highlighting the importance of support systems in navigating the challenges of caring for premature infants.
Intratracheal administration of budesonide with surfactant for prevention of death or bronchopulmonary dysplasia in extremely low birth weight infants - a before-after study.
Am J Perinatol
December 2024
Neonatology, Surya Hospitals, Mumbai, India.
Article Synopsis
- The study explored the role of intratracheal budesonide combined with surfactant in reducing death or bronchopulmonary dysplasia (BPD) in extremely low birth weight (ELBW) infants with respiratory distress syndrome (RDS).
- The results showed no significant difference in the rates of death or BPD between the group that received the combination treatment and the historical group that received surfactant alone.
- Although the combination treatment was found to be safe and feasible, further larger studies are needed to confirm any potential benefits.
Response of the ductus arteriosus to acetaminophen or indomethacin in extremely low birth weight infants.
J Perinatol
December 2024
Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37272, USA.
Objective: Acetaminophen and indomethacin are used for medical management of a patent ductus arteriosus. This study compared the efficacy of these agents in ELBW infants.
Study Design: This was a retrospective study of all courses of indomethacin and acetaminophen.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!