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[Teratovigilance. Antiepileptics during pregnancy and paternal use].
Rev Med Suisse
January 2025
Swiss Teratogen Information Service, Service de pharmacologie clinique, Département de médecine, Centre hospitalier universitaire vaudois, 1011 Lausanne.
The 2023-2024 updates on teratovigilance, with a focus on antiseizure medications, highlight several key points. American medical societies have revised their recommendations: maintaining effective seizure control is essential for both maternal and fetal health; lamotrigine, levetiracetam, and oxcarbazepine are preferred first-line treatments, whereas valproic acid and topiramate should be avoided if possible. In March 2024, an update on topiramate indicated an increased risk of neurodevelopmental disorders with prenatal exposure.
View Article and Find Full Text PDFHair Straightener Use in Relation to Prevalent and Incident Fibroids in the Sister Study with a Focus on Black Women.
Environ Health Perspect
January 2025
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Background: Uterine fibroids disproportionately affect Black women, and exposure to chemicals from hair relaxers or straighteners ("straighteners") may contribute to fibroid development.
Objectives: We examined the association between straightener use and prevalent young-onset uterine fibroids (diagnosed before age 36 y), as well as incident fibroids (diagnosed age 36-60 y), with a focus on Black women. We also examined differences in associations across birth cohorts as proxies for formulation changes.
Recommended Occupational Exposure Limits for GMA Using Benchmark Dose and Bayesian Model Averaging.
China CDC Wkly
December 2024
Chinese Center for Disease Control and Prevention, Beijing, China.
Introduction: Glycidyl methacrylate (GMA) is a widely used industrial polymerization material. Current occupational exposure limits (OELs) for GMA in China show significant disparities compared to those established by international regulatory bodies, including the United States, the European Union, and Japan. A comprehensive revision of GMA exposure limits is crucial for ensuring optimal worker protection.
View Article and Find Full Text PDFAssociations of prenatal maternal psychosocial stress and depression with neurodevelopmental outcomes in 7.5-month-old infants in the ECHO.CA.IL prospective birth cohorts.
Neurotoxicol Teratol
January 2025
University of Illinois Urbana-Champaign, Beckman Institute for Advanced Science and Technology, 405 N. Mathews Ave., Urbana, IL 61821, USA. Electronic address:
Background: Exposure to maternal stress and depression during pregnancy can have a marked impact on birth outcomes and child development, escalating the likelihood of preterm birth, lower birth weight, and various domains of physical and neurodevelopment.
Methods: The joint ECHO.CA.
Intersection of rare pathogenic variants from TCGA in the All of Us Research Program v6.
HGG Adv
January 2025
Department of Biology, Brigham Young University, Provo, UT, 84061, USA; Simmons Center for Cancer Research, Brigham Young University, Provo, UT 84602, USA. Electronic address:
Using rare cancer predisposition alleles derived from The Cancer Genome Atlas (TCGA) and high cancer prevalence (14% of participants) in All of Us (version 6), we assessed the impact of these rare alleles on cancer occurrence in six broad groups of genetic similarity provided by All of Us: African/African American (AFR), Admixed American/Latino (AMR), East Asian (EAS), European (EUR), Middle Eastern (MID), or South Asian (SAS). We observed that germline susceptibility to cancer consistently replicates in EUR-like participants but less so in other participants. We found that All of Us participants from the EUR (p = 1.
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