Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/anie.200503054 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The pond snail Lymnaea stagnalis.
Evodevo
December 2020
Frontier Research Institute, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi, 487-8501, Japan.
The freshwater snail Lymnaea stagnalis has a long research history, but only relatively recently has it emerged as an attractive model organism to study molecular mechanisms in the areas of developmental biology and translational medicine such as learning/memory and neurodegenerative diseases. The species has the advantage of being a hermaphrodite and can both cross- and self-mate, which greatly facilitates genetic approaches. The establishment of body-handedness, or chiromorphogenesis, is a major topic of study, since chirality is evident in the shell coiling.
View Article and Find Full Text PDFNatural reversal of left-right gut/gonad asymmetry in C. elegans males is independent of embryonic chirality.
Genesis
June 2014
Department of Molecular, Cellular and Developmental Biology and Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California; Department of Computer Science, University of California Santa Barbara, Santa Barbara, California.
Anatomical left-right (L/R) asymmetry in C. elegans is established in the four-cell embryo as a result of anteroposterior skewing of transverse mitotic spindles with a defined handedness. This event creates a chiral embryo and ultimately an adult body plan with fixed L/R positioning of internal organs and components of the nervous system.
View Article and Find Full Text PDFEvolution of mirror images by sexually asymmetric mating behavior in hermaphroditic snails.
Am Nat
August 1998
Division of Biology, Tokyo Metropolitan College, Azuma-cho, Akishima-shi, Tokyo 196-8540, Japan.
Directionally asymmetric animals generally exhibit no variation in handedness of whole-body architecture. In contrast, reversed chirality in both coil and entire anatomy has frequently evolved in snails. We demonstrate a nonrandom pattern and deterministic process of chiral evolution, as predicted by the following hypothesis.
View Article and Find Full Text PDFPharmacokinetic profile of dexloxiglumide.
Clin Pharmacokinet
February 2007
Departments of Clinical Pharmacology and Drug Metabolism, Pharmacokinetics and Dynamics, Rotta Research Laboratorium-Rottapharm, Monza, Italy.
Dexloxiglumide is a potent and selective cholecystokinin type 1 (CCK1) receptor antagonist currently under development in a variety of diseases affecting the gastrointestinal tract such as gastro-oesophageal reflux disease, irritable bowel syndrome (IBS), functional dyspepsia, constipation and gastric emptying disorders. In female patients with constipation-predominant IBS, clinical efficacy has been demonstrated following administration of dexloxiglumide 200 mg three times daily. Dexloxiglumide is rapidly and extensively absorbed after single oral administration in humans with an absolute bioavailability of 48%.
View Article and Find Full Text PDFDisassociation between weak sexual isolation and genetic divergence in a hermaphroditic land snail and implications about chirality.
J Evol Biol
September 2006
Department of Animal Biology, Faculty of Biology, University of Patras, 26500 Patras, Greece.
Examination of the association between reproductive isolation and genetic divergence in a variety of organisms is essential for elucidating the mechanisms causing speciation. However, such studies are lacking for hermaphrodites. We measured premating (sexual) isolation in species pairs of the hermaphroditic land snail Albinaria and we compared it with their genetic divergence.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!