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Association Between Serum Antinuclear Antibody and Polycystic Ovarian Syndrome in Reproductive Women Aged 18 to 35 Years: A Quest for an Autoimmune Marker.
Cureus
December 2024
Obstetrics and Gynaecology, All India Institute of Medical Sciences, Raipur, IND.
Introduction: Polycystic ovarian syndrome (PCOS) is a heterogeneous endocrinal physiological disorder characterized by chronic oligo-ovulation or an-ovulation, hyperandrogenism, and polycystic morphology in ovaries on transvaginal or abdominal ultrasound. Hyperandrogenism and insulin resistance are already well-documented pathophysiological mechanisms in PCOS. Besides this, autoimmunity has been hypothesized in its pathogenesis.
View Article and Find Full Text PDFMetabolic interventions as adjunctive therapies to insulin in type 1 diabetes: Current clinical landscape and perspectives.
Diabetes Obes Metab
January 2025
Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Type 1 diabetes (T1D) is classically characterized as an autoimmune disease wherein the immune system erroneously attacks insulin-producing pancreatic β-cells, causing insulin insufficiency and severe metabolic dysregulation. However, intensive investigation and numerous clinical trials with immunotherapies have been largely unable to significantly alter the course of disease. Currently, there is no effective way to prevent or cure T1D, and insulin remains the cornerstone of T1D treatment.
View Article and Find Full Text PDFInhibition of leukotrienes and their potential role in type 1 diabetes pathogenesis: implications for montelukast as a therapeutic agent: a case report.
Front Clin Diabetes Healthc
December 2024
Department of Medicine, NU Hospital Group, Trollhättan and Uddevalla, Sweden.
Introduction: Type 1 diabetes involves immune-mediated destruction of insulin-producing beta cells, with eosinophils potentially playing a significant role. Recent studies suggest that leukotriene inhibition might influence this process. This case report presents a novel observation of montelukast, a leukotriene receptor antagonist, reducing insulin requirements in a patient with Latent Autoimmune Diabetes in Adults (LADA).
View Article and Find Full Text PDFRBM47 as a potential therapeutic target for thyroid-associated ophthalmopathy.
Int Immunopharmacol
January 2025
Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:
RNA-binding motif 47 (RBM47) is a recently identified RNA-binding protein involved in early vertebrate development, immune homeostasis, and cancer development. This study examined the biological functions of RBM47 in thyroid-associated ophthalmopathy (TAO). Orbital fibroblasts (OFs) were obtained from the control (n = 6) and TAO groups (n = 6).
View Article and Find Full Text PDFThe N6-methyladenosine RNA epigenetic modification modulates the amplification of coxsackievirus B1 in human pancreatic beta cells.
Front Microbiol
December 2024
ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium.
Article Synopsis
- Type 1 diabetes (T1D) results from an autoimmune attack that destroys insulin-producing beta cells, with its initiation linked to genetic, immunological, and environmental factors, particularly viral infections like Coxsackievirus B (CVB).
- Research reveals that CVB serotype 1 (CVB1) may trigger autoimmune responses in genetically susceptible individuals, but the exact mechanisms of its replication in beta cells are unclear.
- New findings indicate that the N6-methyladenosine (m6A) modification influences CVB1 amplification, where downregulating m6A "writers" increases viral replication, while inhibiting "erasers" like FTO significantly decreases infectious CVB1 production, highlighting m6A's role
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