Aims: To investigate the long-term effects of efavirenz on cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL-C) and triglycerides (TG).
Methods: Thirty-four HIV-infected patients who commenced efavirenz therapy were monitored for 36 months.
Results: In patients with baseline HDL-C<40 mg.dL-1 an increase in HDL-C from 31+/-1 mg.dL-1 to 44+/-2 mg.dL-1 (95% confidence interval 5.9, 21.9, P<0.01) was observed and remained throughout the follow-up period. Median efavirenz plasma concentration was 1.98 mg.L-1 and a direct correlation between percentage of HDL-C variation or TC/HDL-C ratio and efavirenz plasma concentrations was found.
Conclusions: There is evidence of a long-term and concentration-dependent beneficial effect of efavirenz on HDL-C in HIV-infected patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885052 | PMC |
| http://dx.doi.org/10.1111/j.1365-2125.2006.02619.x | DOI Listing |
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