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Mind the Gap: A Neural Network Framework for Imputing Genotypes in Non-Model Species.
Mol Ecol Resour
January 2025
Section for Molecular Ecology and Evolution, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
Reduced representation sequencing (RRS) has proven to be a cost-effective solution for sequencing subsets of the genome in non-model species for large-scale studies. However, the targeted nature of RRS approaches commonly introduces large amounts of missing data, leading to reduced statistical power and biased estimates in downstream analyses. Genotype imputation, the statistical inference of missing sites across the genome, is a powerful alternative to overcome the caveats associated with missing sites.
View Article and Find Full Text PDFDon't mind the gap: reframing the Perren strain rule for fracture healing using insights from virtual mechanical testing.
Bone Joint Res
January 2025
Department of Mechanical Engineering & Mechanics, Lehigh University, Bethlehem, Pennsylvania, USA.
Aims: The "2 to 10% strain rule" for fracture healing has been widely interpreted to mean that interfragmentary strain greater than 10% predisposes a fracture to nonunion. This interpretation focuses on the gap-closing strain (axial micromotion divided by gap size), ignoring the region around the gap where osteogenesis typically initiates. The aim of this study was to measure gap-closing and 3D interfragmentary strains in plated ovine osteotomies and associate local strain conditions with callus mineralization.
View Article and Find Full Text PDFBilateral primary vitreoretinal lymphoma masquerading as fungal endophthalmitis- a case report.
J Ophthalmic Inflamm Infect
December 2024
Shroff Eye Center, Kailash Colony, New Delhi, India.
Purpose: To report a case of bilateral primary vitreoretinal lymphoma (PVRL) masquerading as endophthalmitis in a patient with a history of bilateral cataract surgery and COVID-19.
Observation: A 60-year-old male patient presented with diminution of vision in both the eyes. There was a history of bilateral cataract surgery done 2 months back at a gap of one week and COVID-19 infection treated with high dose systemic corticosteroids.
Supplemental Intervention for Alcohol Use Disorder Treatment Patients With a Co-Occurring Anxiety Disorder: Technical Development and Functional Testing of an Autonomous Digital Program.
JMIR Form Res
December 2024
Department of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, MN, United States.
Background: Anxiety disorders are common in alcohol use disorder (AUD) treatment patients. Such co-occurring conditions ("comorbidity") have negative prognostic implications for AUD treatment outcomes, yet they commonly go unaddressed in standard AUD care. Over a decade ago, we developed and validated a cognitive behavioral therapy intervention to supplement standard AUD care that, when delivered by trained therapists, improves outcomes in comorbid patients.
View Article and Find Full Text PDFWheelchair user's perceived access to maintenance and repair services: a qualitative study.
Disabil Rehabil Assist Technol
December 2024
Department of Rehabilitation Science and Technology, University of Pittsburgh, Pittsburgh, PA, USA.
Purpose: Wheelchairs and associated seating and positioning systems require maintenance and repair services to sustain essential functions for wheelchair users. This study aims to amplify wheelchair users' opinions and experiences related to their perceived access to crucial wheelchair maintenance and repair services.
Methods: We conducted semi-structured interviews with four full-time wheelchair users using five semi-structured interview questions.
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