A 42-year-old man with ataxic tetraparesis is reported. Computerized tomography showed bilateral and symmetrical lacunar infarcts at the junctions of the posterior limb of the internal capsule and the corona radiata. Previously this clinical syndrome had been reported only with a lesion in the pons.
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http://dx.doi.org/10.1016/0303-8467(91)90100-4 | DOI Listing |
Curr Probl Pediatr Adolesc Health Care
November 2024
National Institute of Child Health and Human Development, Israel; Professor of Pediatrics, Division of Pediatrics, Hadassah Hebrew University Medical Center, Kentucky; Children's Hospital, University of Kentucky, Lexington, United States; Professor of Public Health, Center for Healthy Development, School of Public Health, Georgia State University, Atlanta, United States.
Cerebral palsy is a disorder characterized by abnormal tone, posture, and movement. In clinical practice, it is often useful to approach cerebral palsy based on the predominant motor system findings - spastic hemiplegia, spastic diplegia, spastic quadriplegia, extrapyramidal or dyskinetic, and ataxic. The prevalence of cerebral palsy is between 1.
View Article and Find Full Text PDFJ Neurol Neurosurg Psychiatry
June 2024
Neuromuscular Diseases Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Background: Intravenous immunoglobulin (IVIG) and rituximab are considered the first-line and second-line treatments for Chronic Ataxic Neuropathy and Ophthalmoplegia with IgM-paraprotein, cold Agglutinins, and anti-Disialosyl antibodies (CANOMAD), with an overall clinical response around 50%. New anti-CD38 daratumumab, targeting long-lived plasma cells, has been reported as a promising therapy for treatment-refractory antibody-mediated disorders. We report the first case of a severe refractory CANOMAD, successfully treated with daratumumab.
View Article and Find Full Text PDFJ Peripher Nerv Syst
September 2023
Department of Neurosciences, University of Padova, Padova, Italy.
Aim: Nodopathies and paranodopathies are autoimmune neuropathies associated with antibodies to nodal-paranodal antigens (neurofascin 140/186 and 155, contactin-1, contactin-associated protein 1 [Caspr1]) characterized by peculiar clinical features, poor response to standard immunotherapies (e.g., intravenous immunoglobulins, IVIg).
View Article and Find Full Text PDFCureus
August 2022
Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah, SAU.
Background: In developed countries, cerebral palsy (CP) is the most common neurological disorder in children. It is defined as a non-progressive disturbance to the developing brain leading to motor impairment that affects the child's activity. CP is classified into three main subtypes: ataxic, spastic, and mixed.
View Article and Find Full Text PDFJ Child Neurol
August 2021
Department of Radio-diagnosis, 76140King George's Medical University, Lucknow, Uttar Pradesh, India.
Background: Few studies have focused on magnetic resonance imaging (MRI) brain findings associated with functional mobility in cerebral palsy.
Objective: To determine association between MRI findings and Gross Motor Functional Classification System (GMFCS) levels in cerebral palsy.
Methods: Prospective-observational study conducted in Pediatric Neurology Clinic at a public teaching hospital, Northern India.
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