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| http://dx.doi.org/10.1104/pp.35.6.848 | DOI Listing |
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Unravelling the modes of phototoxicity of NIR absorbing chlorophyll derivative in cancer cells under normoxic and hypoxic conditions.
Photochem Photobiol Sci
January 2025
Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai, 400094, India.
The efficacy of photodynamic treatment (PDT) against deep-seated tumor is hindered by low penetration depth of light as well as hypoxic conditions which prevails in tumor. To overcome this limitation, Near-infrared (NIR) absorbing photosensitizers have been investigated actively. In the present study we evaluated the PDT efficacy of an NIR absorbing chlorophyll derivative 'Cycloimide Purpurin-18 (CIPp-18)' in Human Breast carcinoma (MCF-7) and cervical adenocarcinoma (Hela) cells under normoxic and hypoxic conditions.
View Article and Find Full Text PDFUtilising terahertz pulsed imaging to analyse the anhydrous-to-hydrate transformation of excipients during immediate release film coating hydration.
Int J Pharm
December 2024
Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge, CB3 0AS, UK. Electronic address:
Pharmaceutical tablets are routinely film-coated to improve appearance, reduce medication errors and enhance storage stability. Terahertz pulsed imaging (TPI) can be utilised to study the liquid penetration into the porous tablet matrix in real time. Using polymer-coated flat-faced tablets with anhydrous lactose or mannitol, we show that when the tablet matrix contains anhydrous material, the anhydrous form transforms to the solid-state hydrate form in the tablet core while the immediate release coating dissolves.
View Article and Find Full Text PDFInvestigating the effects of formulation variables on the disintegration of spray dried amorphous solid dispersion tablets.
J Pharm Sci
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Synthetic Molecule Pharmaceutical Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:
Amorphous solid dispersion (ASD) tablets based on hydrophilic polymer carriers may encounter disintegration challenges. In this work, the effect of different formulation composition variables on the ASD tablet disintegration performance was systematically studied. GDC-0334: copovidone (PVPVA) 60: 40 ASD prepared by spray drying was selected as the model ASD system.
View Article and Find Full Text PDFChemically Driven Clearance of Amyloid Aggregates by Polyfunctionalized Furo[2,3-:4,5-']dipyridine-Chalcone Hybrids to Ameliorate Memory in an Alzheimer Mouse Model.
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Department of Integrative Biotechnology & Translational Medicine, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Republic of Korea.
Article Synopsis
- The accumulation of amyloid-β (Aβ) is linked to Alzheimer's disease, and recent studies suggest that targeting Aβ may be a viable treatment strategy.
- Researchers developed 51 new compounds aimed at enhancing the clearance of Aβ aggregates, with one promising candidate, YIAD-0336, showing potential through various functional assays.
- Upon testing in mice, YIAD-0336 demonstrated the ability to improve memory and significantly reduce Aβ plaques, indicating its potential as a treatment for cognitive decline associated with Alzheimer’s disease.
Adverse Environmental Perturbations May Threaten Kelp Farming Sustainability by Exacerbating Enterobacterales Diseases.
Environ Sci Technol
April 2024
Institute of Marine Microbes and Ecospheres, State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361100, China.
Globally kelp farming is gaining attention to mitigate land-use pressures and achieve carbon neutrality. However, the influence of environmental perturbations on kelp farming remains largely unknown. Recently, a severe disease outbreak caused extensive kelp mortality in Sanggou Bay, China, one of the world's largest high-density kelp farming areas.
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