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Modifiable risk factors and symptom progression in dementia over up to 8 years-Results of the DelpHi-MV trial.
Alzheimers Dement (Amst)
January 2025
Health Care Research Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Greifswald Mecklenburg-Vorpommern Germany.
Introduction: This study investigated the association between modifiable factors and symptom progression in dementia over up to 8 years.
Methods: Multilevel growth curve models assessed the role of modifiable risk factors (low education, hearing impairment and its treatment, depression, physical inactivity, diabetes and its treatment, smoking, hypertension and its treatment, obesity, alcohol consumption, social isolation, and visual impairment) on cognitive and functional trajectories in 353 people with dementia.
Results: Higher education was associated with higher initial cognitive status but faster decline.
Urinary biomarkers for diagnosing acute kidney injury in sepsis in the emergency department.
Heliyon
January 2025
Department of Emergency Medicine, Seoul National University Bundang Hospital (SNUBH), Seongnam-si, South Korea.
Background: Development of acute kidney injury (AKI) in patients with sepsis is associated with increased mortality, highlighting the importance of early detection and management. However, baseline creatinine or urine output measurements are required for AKI diagnosis, which can be challenging in emergency departments (EDs). We aimed to evaluate the association between urinary biomarkers and the AKI diagnosis or 30-day survival status in patients with sepsis in the ED.
View Article and Find Full Text PDFChanges in life satisfaction, self-esteem, and self-rated health before, during, and after becoming a young carer in the UK: a longitudinal, propensity score analysis.
Lancet Reg Health Eur
March 2025
Research Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK.
Background: The health of young carers is poorer, on average, than their peers. The timing and persistence of health and wellbeing changes around becoming a young carer are unknown. We investigated how health and wellbeing change before, during and after becoming a young carer in the UK and whether this varies by caring intensity, age, gender, ethnicity, or household income.
View Article and Find Full Text PDFMapping Trajectories of Gait Recovery in Clinical Stroke Rehabilitation.
Neurorehabil Neural Repair
January 2025
Department of Human Movement Science, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands.
Background: How gait changes during the early stages of stoke rehabilitation, and which patient characteristics are associated with these changes is still largely unknown.
Objective: he first objective was to describe the changes in gait during stroke rehabilitation. Secondly, we determined how various patient characteristics were associated with the rate of change of gait over time.
The mediating role of maternal fasting plasma glucose level and lipid levels in the third trimester of pregnancy between pre-pregnancy BMI and offspring physical development at birth.
Eur J Pediatr
January 2025
School of Nursing, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Unlabelled: While previous research has established correlations between pre-pregnancy body mass index (BMI), late-pregnancy blood glucose, and late-pregnancy blood lipid levels during pregnancy and offspring's physical development, the underlying mechanism of their interaction remains elusive. A birth cohort study was conducted on pregnant women, who are biologically female, delivering at a tertiary hospital in Wuhan City between May 2023 and April 2024, encompassing 1620 participants. We collected maternal socio-demographic data through questionnaires and obtained information on fasting blood glucose (FPG), lipid levels during the third trimester, and neonatal physical development from medical records.
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