AI Article Synopsis
- Antibiotic treatment for deep-seated staphylococcal infections tied to orthopedic implants often fails, highlighting a challenge in these cases.
- Standard antibiotics like semi-synthetic penicillins and cephalosporins work well as preventive measures but struggle to treat existing infections effectively.
- The mechanisms causing this treatment failure, including bacterial tolerance to antibiotics, are not fully understood, suggesting a need for further research.
Article Abstract
Antibiotic therapy for deep-seated staphylococcal infections, especially when they are associated with artificial devices used for orthopedic surgery is often associated with failure. Standard anti-staphylococcal bactericidal antibiotics, such as semi-synthetic penicillins, cephalosporins, or glycopeptides, are effective when given prophylactically in clinical conditions or experimental trials of implant-related infections. However, the efficacy of all anti-staphylococcal agents is seriously diminished on already established implant-related deep-seated infections, which then frequently require surgical implant removal to obtain a cure. The failure of antibiotic therapy to cure established staphylococcal foreign-body infections may arise in part from a broad-spectrum phenotypic tolerance expressed in vivo to different classes of antimicrobial agents. The molecular and physiological mechanisms of this in vivo tolerance remain poorly understood.
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| http://dx.doi.org/10.1016/j.injury.2006.04.004 | DOI Listing |
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