Sarcomatoid chromophobe renal cell carcinoma. A case report and review of the literature.

Arch Esp Urol

Service of Pathology, Vargas Hospital, José María Vargas School of Medicine, Central University of Venezuela, Caracas.

Published: March 2006

Objectives: We report herein the clinical, histological, and immunohistochemical features of a case of sarcomatoid chromophobe renal cell carcinoma.

Methods/results: A 59-year-old woman referred a two-month history of constant right flank pain, and hematuria. A right radical nephrectomy was performed. Gross pathologic examination showed a tumor located in the lower part of the kidney with two different aspects. Histologically, the tumor was composed of two intermixed distinct morphologic components: a chromophobe renal cell carcinoma and a high-grade spindle cell sarcoma.

Conclusion: Our case represent a typical sarcomatoid chromophobe cell carcinoma. This unusual renal cancer has the potential to behave aggressively and to metastasize.

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http://dx.doi.org/10.4321/s0004-06142006000200018DOI Listing

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