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SAMHD1 shapes deoxynucleotide triphosphate homeostasis by interconnecting the depletion and biosynthesis of different dNTPs.
Nat Commun
January 2025
Department of Biochemistry and Structural Biology, UT Health San Antonio, San Antonio, TX, USA.
SAMHD1 is a dNTPase that impedes replication of HIV-1 in myeloid cells and resting T lymphocytes. Here we elucidate the substrate activation mechanism of SAMHD1, which involves dNTP binding at allosteric sites and transient tetramerization. Our findings reveal that tetramerization alone is insufficient to promote dNTP hydrolysis; instead, the activation mechanism requires an inactive tetrameric intermediate with partially occupied allosteric sites.
View Article and Find Full Text PDFPreventive vs. Therapeutic Effects of Shoutai Wan: Maintaining an Acidic Microenvironment at the Maternal-Fetal Interface to Promote Angiogenesis and Minimize Pregnancy Loss in RSA Mice.
J Ethnopharmacol
January 2025
College of Integrated Traditional Chinese and Western Medicine, Hebei University of Chinese Medicine, Shijiazhuang, 050091, China; Collaborative Innovation Center of Integrated Chinese and Western Medicine on Reproductive Disease, Shijiazhuang, 050091, China; Hebei Key Laboratory of Integrative Medicine on Liver-kidney Patterns, Shijiazhuang, 050091, China. Electronic address:
Ethnopharmacological Relevance: The classic TCM prescription, Shoutai Wan (STW), is extensively used in clinical settings to manage threatened miscarriage and Recurrent spontaneous abortion (RSA). The complexity of pregnancy physiology, coupled with diverse etiologies, and the specificity of energy metabolism for normal embryo attachment and development,pose challenges to clinical diagnosis and treatment. The specific molecular mechanisms of how STW regulates these biological processes and contributes to the treatment of RSA remain to be elucidated.
View Article and Find Full Text PDFA scoping review of studies reporting biosecurity practices in small and backyard farms raising livestock or poultry in developed countries, 2000-2022.
Prev Vet Med
January 2025
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, United States. Electronic address:
Over the past two decades, there have been growing concerns around small and backyard farms in developed countries due to the potential risk they pose in introducing and spreading infectious disease agents. Ensuring high levels of biosecurity on these farms, through the maintenance of practices that prevent the introduction and transmission of disease agents, is essential in mitigating this risk. The aim of this study was to investigate, through a scoping review, the practices considered in articles reporting biosecurity in small and backyard farms raising livestock or poultry in developed countries, and how their implementation was examined.
View Article and Find Full Text PDFThe BMP Signaling Pathway: Bridging Maternal-Fetal Crosstalk in Early Pregnancy.
Reprod Sci
January 2025
Shanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Medical School, Fudan University, Shanghai, 200237, China.
The maintenance of early pregnancy is a complex and distinctive process, primarily characterized by critical reproductive events such as embryo implantation, trophoblasts differentiation, decidualization, and extravillous trophoblasts (EVTs) invasion etc. However, dysregulation of these essential reproductive processes can result in various pregnancy complications, including recurrent miscarriage, preeclampsia, and fetal growth restriction etc. Notably, these complications exhibit an interconnected regulatory network that suggests shared underlying pathophysiological mechanisms.
View Article and Find Full Text PDFSevere sepsis-associated acute kidney injury and outcomes: a longitudinal cohort study.
Intern Med J
January 2025
School of Medicine, Flinders University, Adelaide, South Australia, Australia.
Background: Sepsis-associated acute kidney injury (SA-AKI) is common among patients admitted to the intensive care unit (ICU) with sepsis.
Aims: This study aimed to demonstrate an association between an episode of SA-AKI and progression to dialysis dependence, with a view to identifying a cohort who may be suitable for intensive nephrology follow-up.
Methods: Design: Retrospective data-linkage cohort study.
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