Purpose: The study compares the importance of tilt-table testing and Schellong's test for the diagnosis of syncopes.
Patients And Methods: In a prospective clinical trial 100 consecutive patients (45 males, 55 females) were included. The index symptom for inclusion was a former syncope or presyncope in the patients' history. The tilt-table testing procedure was performed according to a modified version of the Westminster protocol. Following this procedure, Schellong's test was performed in 83 of the patients.
Results: During tilt-table testing 34 patients suffered from orthostatic dysautonomy with syncope or neuro-cardiogenic syncope. 29 of these symptomatic patients also underwent Schellong's test. However, only four patients showed a borderline positive finding, whereas a clearly positive result was seen in six patients. These patients had shown orthostatic dysautonomies with syncopes during tilt-table testing. No patient suffered from a syncope or presyncope during Schellong's test.
Conclusion: Schellong's test is suitable as a diagnostic procedure for orthostatic dysregulation only, and tilt-table testing is highly superior for objectification of the diagnosis and differentiation of syncope.
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http://dx.doi.org/10.1007/s00063-006-1024-x | DOI Listing |
PLoS One
January 2025
Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Background: Visual dysfunction, including abnormal stereopsis, is a significant non-motor symptom in Parkinson's disease (PD) that can reduce quality of life and appears early in the disease. Abnormal stereopsis is associated with worsening of bradykinesia and freezing of gait, though the exact pathways linking stereopsis to motor symptoms remain unclear. Furthermore, in PD patients, the pedunculopontine nucleus and laterodorsal tegmental complex play an active role in sensorimotor control, and these areas provide cholinergic projections.
View Article and Find Full Text PDFHeart Rhythm
January 2025
Centre for Cardiovascular Research and Nutrition, C2VN, INSERM, INRAE, AMU, Marseille, France; Laboratory of Biochemistry, AP-HM, Marseille, France.
Eur Heart J
December 2024
Department of Cardiology, IRCCS Istituto Auxologico Italiano, Faint and Fall Research Centre, S. Luca Hospital, Piazzale Brescia 20, Milano 20149, Italy.
Background And Aims: Identifying the haemodynamic mechanism of autonomic syncope is the essential pre-requisite for effective and personalized therapy aimed at preventing recurrences. The present study assessed the diagnostic efficacy of a two-step assessment.
Methods: Multicentre prospective, cross-sectional, observational study.
J Clin Med
December 2024
Stichting CardioZorg, Kraayvel 5, 1171 JE Badhoevedorp, The Netherlands.
: While the diagnosis of postural orthostatic tachycardia syndrome (POTS) is based on heart rate (HR) and blood pressure (BP) criteria, the pathophysiology of POTS is not fully understood as multiple pathophysiological mechanisms have been recognized. Also, cardiac function, being dependent on preload, afterload, contractility, and HR, has not been properly studied. Preload and contractility changes can be inferred from stroke volume index (SVI) changes during a tilt test.
View Article and Find Full Text PDFHealthcare (Basel)
December 2024
Stichting Cardio Zorg, Kraayveld 5, 1171 JE Badhoevedorp, The Netherlands.
Introduction: Orthostatic intolerance is highly prevalent in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and is caused by an abnormal reduction in cerebral blood flow (CBF). In healthy controls (HCs), the regulation of CBF is complex and cardiac output (CO) is an important determinant of CBF: a review showed that a 30% reduction in CO results in a 10% reduction in CBF. In previous and separate ME/CFS studies, we showed that CO and CBF decreased to a similar extent during tilt testing.
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