Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Operation of spinal sensorimotor circuits controlling phase durations during tied-belt and split-belt locomotion after a lateral thoracic hemisection.
Elife
January 2025
Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Centre de Recherche du CHUS, Université de Sherbrooke, Sherbrooke, Canada.
Locomotion is controlled by spinal circuits that interact with supraspinal drives and sensory feedback from the limbs. These sensorimotor interactions are disrupted following spinal cord injury. The thoracic lateral hemisection represents an experimental model of an incomplete spinal cord injury, where connections between the brain and spinal cord are abolished on one side of the cord.
View Article and Find Full Text PDFAn evidence-based approach to the recovery of bladder and bowel function after pediatric spinal cord injury.
J Clin Neurosci
October 2023
Department of Neurological Surgery, University of Louisville, Louisville, KY, United States; Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, United States; School of Medicine, University of Louisville, Louisville, KY, United States.
Introduction: Bladder dysfunction and associated complications of the urinary system negatively impact the quality of life in children living with spinal cord injury (SCI). Pediatric lower urinary tract deficits include bladder over-activity, inefficient emptying, decreased compliance, and incontinence. Recent evidence in adults with SCI indicates significant improvements in bladder capacity and detrusor pressure following participation in an activity-based recovery locomotor training (ABR-LT) rehabilitative program.
View Article and Find Full Text PDFOperation regimes of spinal circuits controlling locomotion and the role of supraspinal drives and sensory feedback.
Elife
October 2024
Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Centre de Recherche du CHUS, Université de Sherbrooke, Sherbrooke, Canada.
Article Synopsis
- Mammal locomotion is regulated by a spinal neuronal network that interacts with signals from the brain and sensory feedback from the limbs.
- * The study created a computational model to understand how this spinal network functions during different types of walking, particularly in cats, highlighting how it mimics real-life locomotion under various conditions.
- * Findings indicate that at slower speeds, the spinal network needs sensory feedback to function properly, while at faster speeds, it shifts to different operational modes, suggesting distinct control mechanisms for varying locomotor behaviors like exploring versus escaping.
Neuroprotective agents ineffective in mitigating autonomic dysreflexia following experimental spinal cord injury.
Exp Neurol
December 2024
International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada; Department of Medicine, Division of Physical Medicine and Rehabilitation, University of British Columbia, Vancouver, Canada; GF Strong Rehabilitation Centre, Vancouver Coastal Health, Vancouver, Canada. Electronic address:
Article Synopsis
- The study investigates the cardiovascular dysfunction caused by spinal cord injury (SCI) and assesses the efficacy of four neuroprotective agents in aiding cardiovascular recovery.
- Male Wistar rats were given spinal contusions and treated with Fluoxetine, Glyburide, Valproic acid, and Indomethacin, with outcomes measured through blood pressure changes, locomotor function, and lesion area.
- The results showed that Indomethacin and Valproic acid led to high mortality rates, while Fluoxetine and Glyburide were tolerated, but none of the treatments significantly improved blood pressure control or locomotor function compared to the control group.
Case report: Improvement of gait with adaptive deep brain stimulation in a patient with Parkinson's disease.
Front Bioeng Biotechnol
September 2024
Parkinson Institute of Milan, ASST G.Pini-CTO, Milano, Italy.
Article Synopsis
- Gait disturbances significantly impact the quality of life for Parkinson's disease patients, with current treatments only providing limited benefits.
- Deep brain stimulation (DBS) usually targets symptoms like tremors, but is not very effective for improving gait issues.
- A novel approach called adaptive DBS was tested on one patient, leading to notable improvements in walking and overall symptom management, suggesting it may help optimize stimulation for better gait outcomes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!