A track structure approach to the calculation of the relative strength of localised and delocalised recombination mechanisms leading to composite glow peak 5 in LiF:Mg,Ti following heavy charged particle irradiation is described.
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http://dx.doi.org/10.1093/rpd/nci550 | DOI Listing |
Adv Biol (Weinh)
January 2025
Queensland Micro- and Nanotechnology Centre, Nathan Campus, Griffith University, Brisbane, QLD, 4111, Australia.
Colorectal cancer (CRC) remains a leading cause of cancer-related deaths, creating an urgent need for innovative diagnostic solutions. Mechanobiology, a cutting-edge field that investigates how physical forces influence cell behavior, is now revealing new insights into cancer progression. This research focuses on two crucial players: RhoA and Rac1, small yet powerful proteins that regulate the structure and movement of cancer cells.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, TX, 78712, USA.
Self-assembly plays a critical role in nanoparticle-based applications. However, it remains challenging to monitor the self-assembly of multi-component nanomaterials at a single-particle level, in real-time, with high throughput, and in a model-independent manner. Here, multi-color fluorescence microscopy is applied to track the assembly of both liposomes and mRNA simultaneously in clinical mRNA-based cancer immunotherapy.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Department of Inorganic Chemistry, Fritz-Haber-Institut der Max-Planck-Gesellschaft, Berlin 14195, Germany.
Understanding a catalytic reaction requires tools that elucidate the structure of the catalyst surface and subsurface, ideally at atomic resolution and under reaction conditions. Operando electron microscopy meets this requirement in some cases, but fails in others where the required reaction conditions cannot be reached or lead to an unwanted influence of the electron beam on the reactant and catalyst. We introduce ILIAS (identical location imaging and spectroscopy) in combination with a quasi in situ approach to disentangle the effect of heat and gas on the surface of nanoparticles from the effect of the electron beam.
View Article and Find Full Text PDFVopr Kurortol Fizioter Lech Fiz Kult
January 2025
Petrovsky National Research Centre of Surgery, Moscow, Russia.
Unlabelled: One of the tasks of restorative medicine is the rehabilitation of the body that has suffered from injuries, diseases or adverse environmental effects, and the restoration of the functional reserves of the human body. Currently, a search is underway for new treatment technologies, including the use of wound dressings with specified functional qualities.
Objective: To characterize the effect of a wound dressing based on an ion-track membrane modified with collagen and chitosan nanofibers on the efficiency of skin restoration in experimental animals after a severe thermal burn.
J Mater Chem B
January 2025
Department of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
Nanoparticles capable of dynamically reporting their structural integrity in real-time are a powerful tool to guide the design of drug delivery technologies. Lipid nanoparticles (LNPs) offer multiple important advantages for drug delivery, including stability, protection of active substances, and sustained release capabilities. However, tracking their structural integrity and dynamic behaviour in complex biological environments remains challenging.
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