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Alzheimers Dement
December 2024
Nova Southeastern Dr. Kiran C. Patel College of Osteopathic Medicine - TBR, Clearwater, FL, USA.
Background: Alzheimer's Disease (AD) is a neurodegenerative disease that manifests as memory impairment, cognitive decline, and dementia. Of the preventive measures that exist for AD, research has been ongoing for modifiable risk factors, particularly obesity. The obesity paradox suggests that midlife obesity is a risk factor for AD, while later-life obesity is a protective measure against AD.
View Article and Find Full Text PDFBackground: Cardiovascular (CV) risk factors are associated with increased dementia risk, but their effects on cognition in the oldest-old (90+) are not well studied. CV risk factors may appear to be protective against dementia due to reverse causation when they are measured during dementia process. To clarify this, we studied CV risk factors measured both at midlife and old age, with 48 years of follow-up.
View Article and Find Full Text PDFChronic viral mimicry induction following p53 loss promotes immune evasion.
Cancer Discov
January 2025
Princess Margaret Cancer Centre, Toronto, ON, Canada.
Epigenetic therapies facilitate transcription of immunogenic repetitive elements that cull cancer cells through 'viral mimicry' responses. Paradoxically, cancer-initiating events also facilitate transcription of repetitive elements. Contributions of repetitive element transcription towards cancer initiation, and the mechanisms by which cancer cells evade lethal viral mimicry responses during tumor initiation remain poorly understood.
View Article and Find Full Text PDFA Multimodal Approach to Symptomatic Endometriosis: A Proposed Algorithm for Clinical Management.
Reprod Sci
January 2025
Gynecology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Recent research has proven that peripheral (PS) and central sensitization (CS), mental health, and myofascial dysfunction all play a role, alongside nociception, in the genesis and in the perpetuation of endometriosis' symptoms. However, such components of pain are still largely ignored in clinical practice, although not considering such contributors may entail serious consequences on women's health, including the choice of unnecessary surgery and leaving the real causes of pain untreated. At the present time, we are facing a paradox by which 25-40% of women who undergo laparoscopic surgery for pelvic pain do not have an obvious diagnosis, while the percentage of women with endometriosis who have signs of CS, of depressive or anxiety disorders, or who have an increased pelvic muscle tone ammounts to 41-55%, 15-88% and 28-73%, respectively.
View Article and Find Full Text PDFBackground: Annually, approximately 7.6 million individuals experience a new ischemic stroke, and roughly 25% of all ischemic strokes are cardiogenic in origin, carrying a high risk of recurrence, death and disability. To prevent future ischemic strokes, especially in younger individuals, it is crucial to detect and treat direct and indirect cardioembolic sources.
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