Similar Publications

Case report: Clinical and immunohistochemical manifestations of suspected Sjogren's disease in a dog.

Front Vet Sci

November 2024

Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.

Sjogren's disease, well-described in people, is rarely identified in veterinary species. In people, Sjogren's disease is one of the most common systemic autoimmune disorders with an incidence of 0.5% in the female population.

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A 9-year-old male castrated golden retriever cross was evaluated for an acute onset of ataxia. A complete blood count revealed marked leukocytosis, anemia, and thrombocytopenia. Leukocytosis was characterized by marked lymphocytosis, monocytosis, neutropenia, and eosinopenia.

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Novel ryanodine receptor 1 (RYR1) missense gene variants in two pet dogs with fatal malignant hyperthermia identified by next-generation sequencing.

Vet Anaesth Analg

October 2024

Comparative Pharmacogenomics Laboratory, Program in Individualized Medicine, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA, USA. Electronic address:

Objective: Evaluate a precision medicine approach to confirm a tentative diagnosis of fatal malignant hyperthermia (MH) in isoflurane-anesthetized pet dogs by identifying novel risk variants in known MH susceptibility genes.

Study Design: Retrospective case series.

Animals: A male Pit Bull mix aged 7 years (case #1), a male Golden Retriever aged 12 months (case #2) and the dam and sire of case #2.

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