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Effect of a nutritional supplement on posaconazole pharmacokinetics following oral administration to healthy volunteers. | LitMetric
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Effect of a nutritional supplement on posaconazole pharmacokinetics following oral administration to healthy volunteers.

Angela Sansone-Parsons Gopal Krishna Angela Calzetta David Wexler Bhavna Kantesaria Mitchell A Rosenberg Marc A Saltzman

Antimicrob Agents Chemother

Schering-Plough Research Institute, K-15-4-4455, 2015 Galloping Hill Rd., Kenilworth, NJ 07033, USA.

Published: May 2006

We conducted a randomized, crossover study in healthy adults to examine the effects of a nutritional supplement (Boost Plus) on posaconazole pharmacokinetics. In this study, coadministration of posaconazole with Boost Plus increased the maximum concentration of posaconazole in serum and area under the concentration-time curve from 0 to 72 h values 3.4- and 2.6-fold, respectively, compared to those for the fasted state.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472190PMC
http://dx.doi.org/10.1128/AAC.50.5.1881-1883.2006DOI Listing

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