We report the synthesis and pharmacological properties of several cytisine derivatives. Among them, two 10-substituted derivatives showed much higher selectivities for the alpha4beta2 nAChR subtype in binding assays than cytisine. The 9-vinyl derivative was found to have a very similar agonist activity profile to that of cytisine.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504867 | PMC |
| http://dx.doi.org/10.1021/jm051196m | DOI Listing |
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