We investigated the effect of modeled microgravity (MMG) on normal vascular smooth muscle cells (VSMC) and neoplastic human breast cancer cells (MCF-7). In both cell types, MMG induced partial arrest in G2M and increased p14-3-3, HSP70, HSP60 and p21 expression. Cells synchronized by 24h starvation reentered the normal cycle within 24h if released in complete medium and exposed to normal gravity, but not if exposed to MMG. Similarly, MMG prevented VSMC and MCF-7 cells from overcoming growth arrest and re-synthesizing DNA. This study shows that cells adjust their metabolic rate in response to MMG.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.febslet.2006.03.078 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
IL-4R and CXCR2 Contribute to Downregulating Neutrophil-Mediated Response in the Early Stage of Fungal Extract-Induced Allergic Airway Inflammation.
Biomedicines
November 2024
Department of Immunology, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
: Airborne exogenous antigen inhalation can induce neutrophil infiltration of the airways, while eosinophils migrate to the airways in allergic airway inflammation. During a bacterial infection, Th2-associated cytokine IL-4, by binding to the IL-4 receptor (IL-4R), can suppress neutrophil recruitment to the site of inflammation. In the present study, we estimated whether the IL-4-dependent suppression of neutrophil recruitment contributed to the development of an immune response in asthma.
View Article and Find Full Text PDFCordycepin ameliorates spaceflight-induced osteoporosis by preventing BMSCs oxidative stress and senescence via interacting with PI3K p110α and regulating PI3K/Akt/FOXO3 signalling.
Free Radic Biol Med
December 2024
Institute of Rocket Force Medicine, Third Military Medical University (Army Medical University), 400038, Chongqing, China; State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University (Army Medical University), 400038, Chongqing, China. Electronic address:
Spaceflight-induced osteoporosis (SFOP) is a detrimental healthcare consequence during spaceflight. Weightlessness and ionizing radiation were main environmental factors that contribute to SFOP, especially in the manned deep space voyages. However, currently there is scarce effective method to treat SFOP.
View Article and Find Full Text PDFFacial Expression Perception and Psychological Changes During Space Analogs.
Aerosp Med Hum Perform
December 2024
Introduction: Facial expression perception is the process by which someone can interpret the emotion of another individual using their facial cues. Below-average scores on tests designed to measure facial expression recognition (FER) accuracies are associated with inappropriate behavioral responses and are often linked to mental or neurological disorders. Head-down bed rest microgravity analog studies show changes in facial emotion processing that may indicate a behavioral health risk during spaceflight.
View Article and Find Full Text PDFTwo novel triazine-based quaternary ammonium salt Gemini surfactants as potential corrosion inhibitors for carbon steel in a sulfate-reducing bacteria solution: Experimental and theoretical studies.
Heliyon
December 2024
School of Chemistry and Chemical Engineering, North University of China, Taiyuan, 030051, Shanxi, China.
In this paper, two triazine ring-containing quaternary ammonium salt Gemini surfactants (C-2-C and C-2-C) were synthesized. The minimum inhibitory concentrations against sulfate-reducing bacteria (SRB) of C-2-C, C-2-C and dodecyl dimethyl benzyl ammonium chloride (1227) were determined using the double-dilution method. The performance of C-2-C and C-2-C in inhibiting carbon steel corrosion in the presence of SRB was examined, with 1227 serving as a control sample.
View Article and Find Full Text PDFSimulated Microgravity can Promote the Apoptosis and Change Inflammatory State of Kupffer Cells.
Biomed Environ Sci
October 2024
Department of General Surgery, the 306th Hospital of PLA-Peking University Teaching Hospital, Beijing 100101, China;Department of General Surgery, the Ninth Medical Center of PLA General Hospital, Beijing 100101, China.
Objective: In this study, we analyzed the transcriptome sequences of Kupffer cells exposed to simulated microgravity for 3 d and conducted biological experiments to determine how microgravity initiates apoptosis in Kupffer cells.
Methods: Rotary cell culture system was used to construct a simulated microgravity model. GO and KEGG analyses were conducted using the DAVID database.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!