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Opicapone as adjunct to levodopa in treated Parkinson's disease without motor complications: A randomized clinical trial.
Eur J Neurol
January 2025
Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Background: Catechol-O-methyl transferase (COMT) inhibitors are routinely used to manage motor fluctuations in Parkinson's disease (PD). We assessed the effect of opicapone on motor symptom severity in levodopa-treated patients without motor complications.
Methods: This was a randomized, double-blind, 24-week, placebo-controlled study of opicapone 50 mg as adjunct to levodopa (NCT04978597).
Pertactin deficiency of : Insights into epidemiology, and perspectives on surveillance and public health impact.
Hum Vaccin Immunother
December 2024
GSK, GSK Asia House, Singapore, Singapore.
Pertussis resurgence has been documented even in countries with high pediatric vaccine coverage. The proportion of isolates not expressing pertactin (PRN) has increased in several countries where acellular pertussis (aP) vaccines are used. We systematically reviewed published literature up to July 2023 on PRN-negative isolates in MEDLINE and Embase with no geographical limitations, complemented with a gray literature search.
View Article and Find Full Text PDFPertussis vaccination in adults: a behavioral study of physicians from the US, France, and Germany.
BMC Prim Care
November 2024
University of Basel Children's Hospital, Basel, Switzerland.
Background: Pertussis is a highly contagious respiratory tract infection that affects all ages, though it is most severe in young infants. Adults, especially those with respiratory conditions or other chronic illnesses can also suffer serious consequences of pertussis. Pertussis vaccination is the best method of disease prevention in a lifetime.
View Article and Find Full Text PDFVideo-based compilation of acute pain behaviours in cats.
J Feline Med Surg
September 2024
Department of Clinical Sciences, Université de Montréal, St-Hyacinthe, QC, Canada.
Article Synopsis
- The project aimed to create an accessible video resource showcasing acute pain behaviors in cats for veterinary training.
- The database included 60 hours of ethically recorded videos featuring cats at various pain levels, types, and demographic factors, selected based on a specific ethogram.
- A total of 24 edited videos highlighting defined pain behaviors were shared on an open-access platform to enhance the training of veterinary professionals and improve understanding of feline health and behavior.
Opicapone for the treatment of early wearing-off in levodopa-treated Parkinson's disease: pooled analysis of patient level data from two randomized open-label studies.
J Neurol
October 2024
Clinical Investigation Center CIC1436, Departments of Neurosciences and Clinical Pharmacology and NS-Park/FCRIN Network, University of Toulouse 3, University Hospital of Toulouse, INSERM, Toulouse, France.
Background: The wearing-off phenomenon is a key driver of medication change for patients with Parkinson's disease (PD) treated with levodopa. Common first-line options include increasing the levodopa dose or adding a catechol-O-methyltransferase (COMT) inhibitor, but there are no trials comparing the efficacy of these approaches. We evaluated the effectiveness of adjunct opicapone versus an additional 100 mg levodopa dose in PD patients with early wearing-off using pooled data from 2 randomized studies.
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