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Overcoming three-dimensional challenges through objective decomposition and virtual-digital design: A multidisciplinary case on hypodontia treatment.
J World Fed Orthod
March 2025
Assistant professor, State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, China. Electronic address:
A 15-year-old female sought multidisciplinary treatment for hypodontia, three-dimensional problems, deep overbite, multiple occlusal interferences, and collapse of the occlusion. Through virtual-digital design with objective decomposition, this patient underwent five steps of orthodontic treatment under the guidelines of the principles: removal of occlusal restriction is a prerequisite; transverse problems are solved first; then sagittal problems; and vertical correction runs through the treatment. After orthodontic and prosthetic treatment, aesthetic appearance and functional occlusion were achieved.
View Article and Find Full Text PDFEffects of rescue airway pressure release ventilation on mortality in severe pediatric acute respiratory distress syndrome: a retrospective comparative analysis from India.
Acute Crit Care
February 2025
Department of Biostatistics, Christian Medical College, Vellore, India.
Background: Pediatric acute respiratory distress syndrome (PARDS) has a mortality rate of up to 75%, which can be up to 90% in high-risk patients. Even with the use of advanced ventilation strategies, mortality remains unacceptably high at 40%. Airway pressure release ventilation (APRV) mode is a new strategy in PARDS.
View Article and Find Full Text PDFApplication of chemical pattern recognition and similarity evaluation in electrochemical and HPLC-DAD fingerprints for quality consistency study of herbal medicines.
Anal Chim Acta
May 2025
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China. Electronic address:
Background: Herbal medicines and their preparations play a significant role in healthcare systems, yet concerns remain about their quality consistency. Chemical fingerprinting and multi-component quantitative analysis are the commonly used analytical methods and are widely applied in the quality analysis of herbal medicines. The study uses Gegen Qinlian tablets (GQTs) as a case to propose a comprehensive quality consistency evaluation system.
View Article and Find Full Text PDFStatus of temozolomide use without insurance coverage in patients with aggressive pituitary neuroendocrine tumors.
Endocr J
March 2025
Hypothalamic & Pituitary Center, Moriyama Memorial Hospital, Tokyo 134-0081, Japan.
The 2017 World Health Organization classification described aggressive pituitary neuroendocrine tumor (PitNET) as "a tumor with strong invasiveness and rapid growth, which is difficult to treat with surgery, radiation therapy, or drug therapy," which remains a challenge in the treatment of pituitary tumors. Currently, temozolomide (TMZ) is the first-line treatment for aggressive PitNET. However, it is not yet covered by insurance in Japan.
View Article and Find Full Text PDFHomocysteine levels and cardiovascular disease risk factors in chronic kidney disease (CKD), hypertensive and healthy Nigerian adults: a comparative retrospective study.
BMJ Open
March 2025
Department of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Objectives: To investigate homocysteine (Hcy) levels in individuals with chronic kidney disease (CKD), hypertension and a healthy Nigerian population, and to assess their association with cardiovascular disease (CVD) risk.
Setting: The study was conducted using data from the Ibadan CRECKID (Cardiovascular and Renal Event in People with Chronic Kidney Disease) study in Nigeria.
Participants: A total of 420 adults (aged 18+) categorised into three groups: individuals with stage 2 CKD or higher, hypertensive non-CKD individuals and normotensive individuals.
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