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Genome-based reclassification of as a later heterotypic synonym of .
Int J Syst Evol Microbiol
January 2025
Independent Scholar, Singapore, Singapore.
Both the genera and are members of the family . Their type species, both Sanger_33 and ASD5720, were isolated from human faeces. A comparison of their 16S rRNA gene sequences revealed 100% similarity, suggesting their close relatedness and the possibility of belonging to the same species.
View Article and Find Full Text PDFSmall molecules targeting the eubacterial β-sliding clamp discovered by combined and screening approaches.
J Enzyme Inhib Med Chem
December 2025
Laboratory of Biochemistry and Molecular Biology, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy.
Antibiotic resistance stands as the foremost post-pandemic threat to public health. The urgent need for new, effective antibacterial treatments is evident. Protein-protein interactions (PPIs), owing to their pivotal role in microbial physiology, emerge as novel and attractive targets.
View Article and Find Full Text PDFExploring the Impact of Amidation Status in -Diaminopimelic-Acid-Containing Disaccharide Peptidoglycan Fragments on Host Innate Immune Activation.
ACS Chem Biol
January 2025
School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore 637371, Singapore.
Bacterial peptidoglycan, the essential cell surface polymer that protects bacterial integrity, also serves as the molecular pattern recognized by the host's innate immune system. Although the minimal motifs of bacterial peptidoglycan fragments (PGNs) that activate mammalian NOD1 and NOD2 sensors are well-known and often represented by small canonical ligands, the immunostimulatory effects of natural PGNs, which are structurally more complex and potentially can simultaneously activate both the NOD1 and NOD2 signaling pathways in hosts, have not been comprehensively investigated. In particular, many bacteria incorporate additional structural modifications in peptidoglycans to evade host immune surveillance, resulting in diverse structural variations among natural PGNs that may influence their biological effects in hosts.
View Article and Find Full Text PDFCase report: A rare case of bacteremia in an immunocompetent psychiatric patient: exploring the links between mental health and infectious diseases.
Front Immunol
January 2025
Department of Hepatobiliary Surgery, Panzhihua Central Hospital, Sichuan, China.
This study aims to explore the pathogenic potential of as a rare pathogen in immunocompetent individuals and to analyze how mental health status may influence susceptibility to infection. We report a case of bacteremia in a 31-year-old immunocompetent female who developed infection during an episode of severe depression. Although the patient exhibited self-harm tendencies, a thorough physical examination did not reveal any external wounds or signs of injury.
View Article and Find Full Text PDFEffects of prolonged oxytetracycline supplementation on freshwater stinging catfish (): a multi-biomarker approach.
Front Immunol
January 2025
Indian Council of Agriculture Research (ICAR)-Central Institute of Freshwater Aquaculture (CIFA), Fish Health Management Division, Bhubaneswar, Odisha, India.
Background: Aquaculture systems that sporadically depend on antibiotics can contribute to the development of adverse effects on the fish, microbial flora and the environment. This study sought to investigate the impacts of extended oxytetracycline supplementation on the freshwater stinging catfish through a multi-biomarker approach.
Methods: A total of 300 (20 ± 0.
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