Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Bioinformatic Annotation of Transposon DNA Processing Genes on the Long-Read Genome Assembly of s.
Bioinform Biol Insights
December 2024
Cellular Informatics Laboratory, Cluster for Pioneering Research (CPR), RIKEN, Saitama, Japan.
Transposable elements (TEs) or transposons are thought to play roles in animal physiological processes, such as germline, early embryonic, and brain development, as well as aging. However, their roles have not been systematically investigated through experimental studies. In this study, we created a catalog of genes directly involved in replication, excision, or integration of transposon-coding DNA, which we refer to as transposon DNA processing genes (TDPGs).
View Article and Find Full Text PDFGenetic insights and conservation strategies for Amur tigers in Southwest Primorye Russia.
Sci Rep
December 2024
Research Institute for Veterinary Science and Conservation Genome Resource Bank for Korean Wildlife, College of Veterinary Medicine, Seoul National University, Seoul, South Korea.
Article Synopsis
- - Southwest Primorye is home to about 9% of the wild Amur tiger population, which has significantly recovered from fewer than 10 individuals in 1996 due to decades of conservation efforts.
- - A study using non-invasive genetic analysis found 32 Amur tigers and identified issues like low genetic diversity and signs of past population bottlenecks, raising concerns about inbreeding.
- - The findings underscore the necessity to create ecological corridors to connect to other tiger populations for improving genetic diversity and ensuring long-term conservation.
Brain structural connectomic topology predicts medication response in youth with bipolar disorder: A randomized clinical trial.
J Affect Disord
February 2025
Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati 45219, OH, USA.
Background: Response to pharmacotherapy varies considerably among youths with bipolar disorder (BD) and is poorly predicted by clinical or demographic features. It can take several weeks to determine whether medication for BD is clinically effective. Although neuroimaging biomarkers are promising predictors, few studies examined the predictive value of the brain connectomic topology.
View Article and Find Full Text PDFComputer Vision in Digital Neuropathology.
Adv Exp Med Biol
November 2024
School of Computer Science and Engineering, University of New South Wales, Sydney, NSW, Australia.
Article Synopsis
- Digital pathology has transformed neuropathology by allowing quick and accurate examination of tissue samples using digital platforms.* -
- The chapter discusses how computer vision techniques improve diagnostic processes in neuropathology, including early detection of disorders and tumor classification.* -
- It also addresses the challenges and opportunities related to large image datasets and the integration of digital pathology into neurosurgery.*
PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemia.
Nat Commun
November 2024
Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
The epigenetic landscape plays a critical role in cancer progression, yet its therapeutic potential remains underexplored. Glucocorticoids are essential components of treatments for lymphoid cancers, but resistance, driven in part by epigenetic changes at glucocorticoid-response elements, poses a major challenge to effective therapies. Here we show that glucocorticoid treatment induces distinct patterns of chromosomal organization in glucocorticoid-sensitive and resistant acute lymphoblastic leukemia xenograft models.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!