Background: Endothelin (ET-1) may play a role in the regulation of erection but this has not been conclusively demonstrated. Augmented cavernosal smooth muscle (CSM) contraction in the rat occurs following exposure to both ET-1 and phenylephrine (PE; alpha-1 agonist). The aim of this study was to assess the effect of ET-1 and its possible role in the alpha1-adrenergic pathway during the erectile process.
Materials And Methods: Organ bath studies were performed on CSM strips of penises obtained from 12 age-matched New Zealand White rabbits. The effect of ET-1 and PE alone on CSM tone in the absence and presence of ETA (BQ123) and ETB (BQ788) antagonists was assessed. Tissue responses were measured as tension (newton, N). EC50 values are expressed as mean +/- S.E.M.
Results: PE (10(8) - 10(-4) M) and ET-1 (10(-10) - 10(-6) M) produced a concentration-dependent contraction in rabbit CSM strips. The EC50 values were 1.7 x 10(-7) M +/- 1.1 and 3.4 x 10(-9) M +/- 1.5, respectively. BQ123 10(-5) M significantly inhibited ET-1-mediated CSM contractions more than BQ788 10(-5) M (both ANOVA p<0.01). The EC50 were 1.3 x 10(-6) M +/- 2.6 and 2.0 x 10(-7) M +/- 2.1, respectively. Neither the ETA or ETB receptor antagonist had a significant influence on alpha1-adrenergic receptor-mediated CSM contraction.
Conclusion: ETA receptors may play a greater role than ETB receptors in ET-1-induced rabbit CSM contraction and the detumescence process. The a1-adrenergic-dependent pathway does not involve the ETA or ETB receptors.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Objectives: To evaluate wear and friction properties of oscillating strips in order to validate the importance of a standardized interproximal enamel reduction (IPR) sequence to preserve their efficiency and lifetime.
Materials And Methods: Fifteen complete oscillating IPR sequences were tested by means of tribological tests (Linear Reciprocating Tribometer, C.S.
Experimental validation of mechanical oscillating IPR system.
Minerva Dent Oral Sci
February 2024
Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Background: Interproximal enamel reduction (IPR) is a clinical procedure which involves reduction and anatomic recontouring of interproximal surfaces of enamel as a method of gaining space. The biological effects related to this clinical procedure have long been discussed. Thus, the aim of this study was to evaluate the enamel reduction efficiency and the effects on enamel surfaces of the oscillating mechanical system for interproximal enamel reduction (IPR).
View Article and Find Full Text PDFEffects of IPR by mechanical oscillating strips system on biological structures: a quantitative and qualitative evaluation.
Prog Orthod
March 2023
Department of Faculty of Medicine and Surgery, UniCamillus International Medical University, Rome, Italy.
Article Synopsis
- The study aimed to analyze the effects of two different interproximal enamel reduction (IPR) methods on enamel surfaces using advanced techniques like profilometric analysis and scanning electron microscopy (SEM).
- Fifteen teeth were treated with an oscillating IPR sequence (Group 1) and another fifteen with single metallic strips (Group 2), with results showing that Group 1 achieved smoother enamel surfaces with lower roughness and higher waviness.
- The findings suggest that using a standardized oscillating IPR method leads to more regular enamel surfaces, which is important for long-term dental health and better preservation of biological structures.
Long-Term Subjective and Objective Assessment of Smell and Taste in COVID-19.
Cells
February 2022
Department of Sense Organs, Sapienza University, 00161 Rome, Italy.
Among the first clinical symptoms of the SARS-CoV-2 infection is olfactory−gustatory deficit; this continues for weeks and, in some cases, can be persistent. We prospectively evaluated 162 patients affected by COVID-19 using a visual analogue scale (VAS) for nasal and olfactory−gustatory symptoms. Patients were checked after 7, 14, 21, 28, 90, and 180 days.
View Article and Find Full Text PDFCharacterization and functional roles of KCNQ-encoded voltage-gated potassium (Kv7) channels in human corpus cavernosum smooth muscle.
Pflugers Arch
January 2020
Department of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.
The group of KCNQ-encoded voltage-gated potassium (Kv7) channels includes five family members (Kv7.1-7.5).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!