AI Article Synopsis
- About half of lung cancer patients are diagnosed with advanced disease that can't be cured.
- Different chemo regimens and targeted therapies show similar outcomes despite ongoing research in treatment methods.
- Studies have identified genetic factors, like mRNA transcripts and mutations, that could tailor treatments and predict survival rates for patients using specific chemotherapy drugs.
Article Abstract
At the time of diagnosis, half of lung cancer patients have advanced incurable disease. Different chemotherapy combinations--with or without targeted therapies--yield similar results in spite of the continuous efforts of clinicians. However, molecular biological studies have already shed a great deal of light on the existence of multiple genetic aberrations that can be useful for customizing treatment. mRNA transcripts involved in DNA repair pathways, such as ERCC1 and BRCA1, confer selective resistance to cisplatin or taxanes. Polymorphisms in DNA repair genes and methylation of checkpoint genes in circulating serum DNA could become important predictive markers of survival to certain cisplatin-based regimens. EGFR tyrosine kinase mutations are the crux of targeted therapies.
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| http://dx.doi.org/10.1007/s12094-006-0161-2 | DOI Listing |
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