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A 3D millifluidic model of a dermal perivascular microenvironment on a chip.
Lab Chip
January 2025
Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Piazza L. da Vinci, 32, 20133 Milan, Italy.
The process of angiogenesis plays a pivotal role in skin regeneration, ensuring the provision of nutrients and oxygen to the nascent tissue, thanks to the formation of novel microvascular networks supporting functional tissue regeneration. Unfortunately, most of the current therapeutic approaches for skin regeneration lack vascularization, required to promote effective angiogenesis. Thus, tridimensional models, complemented with specific biochemical signals, can be a valuable tool to unravel the neovascularization mechanisms and develop novel clinical strategies.
View Article and Find Full Text PDFNeutrophil dynamics in pulmonary fibrosis: pathophysiological and therapeutic perspectives.
Eur Respir Rev
October 2024
Birmingham Acute Care Research Group, School of Infection, Inflammation and Immunology, University of Birmingham, Birmingham, UK.
Article Synopsis
- - The role of neutrophils, a common type of immune cell, in interstitial lung diseases (ILDs) is under investigation due to their potential involvement in lung tissue damage and repair.
- - Studies show increased neutrophil levels in ILD patients may indicate disease severity, and their proteins and structures can contribute to fibrosis in lung tissue.
- - The review highlights a need for more research on neutrophils as both biomarkers and therapeutic targets, as understanding their actions could lead to better treatment options for ILD.
The endometrial cancer A230V-ALK5 (TGFBR1) mutant attenuates TGF-β signaling and exhibits reduced in vitro sensitivity to ALK5 inhibitors.
PLoS One
November 2024
Reproductive Cancer Genetics Section, Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
The ALK5 (TGFBR1) receptor serine/threonine kinase transduces TGF-β (Transforming Growth Factor beta) signaling to activate SMAD2/3-dependent and -independent pathways. Here, we aimed to determine the functional consequences of ALK5 mutations in human endometrial cancer (EC). Somatic mutation data were retrieved from publicly available databases.
View Article and Find Full Text PDFExploring the Role of miR-132 in Rat Bladders and Human Urothelial Cells during Wound Healing.
Int J Mol Sci
October 2024
Department of Women's and Children's Health, Karolinska Institutet, Biomedicum A4, Tomtebodavägen 16, Solna, 17165 Stockholm, Sweden.
Urinary bladder wound healing shares many features with skin healing, involving several molecular players, including microRNAs (miRs). This study investigated the role of miR-132 in urothelial cells. We analyzed miR-132 expression in rat bladder using in situ hybridization and conducted gain and loss of miR-132 function assays in primary human urothelial cells (HUCs).
View Article and Find Full Text PDFPolyphyllin VI Ameliorates Pulmonary Fibrosis by Suppressing the MAPK/ERK and PI3K/AKT Signaling Pathways via Upregulating DUSP6.
Phytother Res
December 2024
Laboratory of Gastrointestinal Cancer and Liver Disease, Department of Gastroenterology and Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Pulmonary fibrosis (PF) is a lethal disease caused by inordinate repair of damaged lungs, for which limited strategies are available. Polyphyllin VI (PPVI), extracted and isolated from Paris polyphylla Smith var. chinensis (Franch.
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