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Cell-free biodegradable electroactive scaffold for urinary bladder tissue regeneration.
Nat Commun
January 2025
Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Tissue engineering heavily relies on cell-seeded scaffolds to support the complex biological and mechanical requirements of a target organ. However, in addition to safety and efficacy, translation of tissue engineering technology will depend on manufacturability, affordability, and ease of adoption. Therefore, there is a need to develop scalable biomaterial scaffolds with sufficient bioactivity to eliminate the need for exogenous cell seeding.
View Article and Find Full Text PDFModeling bladder mechanics with 4D reconstruction of murine ex vivo bladder filling.
Biomech Model Mechanobiol
December 2024
Department of Mechanical Engineering, Michigan State University, East Lansing, MI, USA.
This study presents a novel methodology for high-resolution 3D bladder modeling during filling, developed by leveraging improved imaging and computational techniques. Using murine bladder filling data, the methodology generates accurate 3D geometries across time, enabling in-depth mechanical analysis. Comparison with a traditional spherical model revealed similar stress trends, but the 3D model permitted nuanced quantifications, such as localized surface curvature and stress analysis.
View Article and Find Full Text PDFDiagnostic accuracy and inter-reader agreement of the nacVI-RADS for bladder cancer treated with neoadjuvant chemotherapy: a prospective validation study.
Eur Radiol
December 2024
Department of Radiological Sciences, Oncology and Pathology, Sapienza University/Policlinico Umberto I, Rome, Italy.
Objective: The primary aim was to determine the performance of neoadjuvant chemotherapy VI-RADS (nacVI-RADS) in predicting response to systemic therapy in patients with MIBC and to evaluate its inter-reader agreement.
Materials And Methods: Prospective study, including patients with non-metastatic muscle-invasive bladder cancer (MIBC) who underwent neoadjuvant chemotherapy before radical cystectomy (RC). Patients underwent pre- and post-treatment MRI.
Aldehyde free - Bovine Pericardium - A New Option of Graft in Urethral Stricture Treatment.
Int Braz J Urol
December 2024
Serviço de Urologia - Hospital Federal da Lagoa, Rio de Janeiro, RJ, Brasil.
Objective: The current management for complex urethral strictures commonly uses open reconstruction with buccal mucosa urethroplasty. However, there are multiple situations whereby buccal mucosa is inadequate (pan-urethral stricture or prior buccal harvest) or inappropriate for utilization (heavy tobacco use or oral radiation). Multiple options exist for use as alternatives or adjuncts to buccal mucosa in complex urethral strictures (injectable antifibrotic agents, augmentation urethroplasty with skin flaps, lingual mucosa, bladder mucosa, colonic mucosa, and new developments in tissue engineering for urethral graft material) (1, 2).
View Article and Find Full Text PDFProspective Analysis of Confocal Laser Endomicroscopy for Assessment of the Resection Bed for Bladder Tumor.
Eur Urol Open Sci
January 2025
Department of Urology, Amsterdam UMC, Amsterdam, The Netherlands.
Background And Objective: Urothelial bladder cancer (UCB) care requires frequent follow-up cystoscopy and surgery. Confocal laser endomicroscopy (CLE), a probe-based optical technique for real-time microscopic evaluation, has shown promising accuracy for grading of UCB. We investigated the diagnostic accuracy of CLE-based assessment of the surgical radicality of the bladder resection bed (RB).
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