Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.schres.2006.03.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Asp/ASPM phospho-regulation throughout the cell cycle.
Genome
January 2025
Department of Biology, Mount St. Vincent University, Halifax, NS B3M 2J6, Canada.
In mammals and , Asp/ASPM proteins contribute to cell proliferation and spindle formation. Recent evidence also suggests interphase roles for Asp/ASPM proteins, but little is known about the regulation allowing distinct roles in different cell cycle phases. In this review, we consider a cross-species comparison of Asp/ASPM protein sequences in light of cyclin-CDK literature, and suggest Asp/ASPM proteins to be prime candidates for cyclin-CDK regulation.
View Article and Find Full Text PDF[Genetic analysis of a child with autosomal recessive primary microcephaly due to variant of ASPM gene and a literature review].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
October 2024
Department of Genetics, Inner Mongolia Maternity and Child Health Care Hospital, Hohhot, Inner Mongolia 010010, China.
Article Synopsis
- This study investigates the clinical and genetic features of a boy diagnosed with autosomal recessive primary microcephaly (MCPH) presented at a health facility in Inner Mongolia due to concerns of microcephaly and mental deficits.
- Through prenatal ultrasounds and whole exome sequencing, researchers identified pathogenic variants in the ASPM gene linked to the child's condition.
- A literature review revealed consistent findings of reduced head size in MCPH cases, along with significant developmental challenges, indicating a strong genetic correlation with the ASPM mutations identified in the study.
Neuroblastoma with high ASPM reveals pronounced heterogeneity and poor prognosis.
BMC Cancer
September 2024
Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China.
Objective: We explored the preliminary value of abnormal spindle-like microcephaly- associated (ASPM) protein in aiding precise risk sub-stratification, prediction of metabolic heterogeneity, and prognosis of neuroblastoma (NB).
Methods: This retrospective study enrolled newly diagnosed patients with NB who underwent positron emission tomography/computed tomography (PET/CT) before therapy, and tumor tissue was collected after surgery. Regression analysis was used to evaluate ASPM expression and risk stratification in patients with NB.
The genetic cause of neurodevelopmental disorders in 30 consanguineous families.
Front Med (Lausanne)
August 2024
Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Fondation Asile Des Aveugles, Lausanne, Switzerland.
Objective: This study aims to clinically and genetically assess 30 unrelated consanguineous Pakistani families from various ethnic backgrounds, all exhibiting features of neurodevelopmental disorders (NDDs).
Methods: We conducted clinical, genetic, biochemical, and molecular analyses on 30 consanguineous families with NDDs enrolled from various regions of Pakistan. The likely molecular causes of primary microcephaly and NDDs were identified.
Promotion of hepatocellular carcinoma stemness and progression by abnormal spindle-like microcephaly-associated protein via the Wnt/β-catenin pathway.
J Gastrointest Oncol
August 2024
Department of Hepatobiliary Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Background: Cancer stem cells (CSCs) play a crucial role in tumor recurrence and metastasis, which are the primary causes of death in patients with hepatocellular carcinoma (HCC). Currently, no drug effectively blocks the recurrence and metastasis of liver cancer, leading to a poor prognosis for patients. To enhance treatment outcomes, there is an urgent need to investigate the molecular mechanisms behind the recurrence and progression of liver cancer, with the aim of identifying effective therapeutic targets.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!