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A role for diet and gut microbiota metabolites in autologous hematopoietic cell transplant recipients.
Blood Cell Ther
November 2024
Clinical Hematology & Medical Oncology.
Introduction: The gut microbiome has an established role in allogeneic hematopoietic cell transplantation (allo-HCT), but not in an auto-HCT setting. We have hypothesized that fecal short-chain fatty acids (SCFA) and urinary 3-indoxyl sulfate (3-IS), which are metabolites derived from the action of the gut microbiome on dietary fiber, play a role in auto-HCT outcomes.
Methods: This was a single-center prospective study involving auto-HCT recipients.
The associations between nutrition and circulating gut microbiota-derived uremic toxins in patients undergoing kidney replacement therapy: An observational, cross-sectional study.
Clin Nutr ESPEN
November 2024
Department of Clinical Nutrition and Dietetics, Medical University of Gdansk, Gdańsk, Poland.
Background: Gut microbiota generates a series of bioactive metabolites that can be converted into uremic toxins such as trimethylamine-N-oxide (TMAO), p-cresyl sulfate (pCS), and indoxyl sulfate (IS). The aim of the study was to examine the association between diet and the concentrations of the mentioned gut microbiota-derived uremic toxins.
Methods: An observational cross-sectional study was conducted involving 210 participants: 84 hemodialysis (HD) patients, 44 peritoneal dialysis (PD) patients, 52 kidney transplant recipients (KTR), and 30 healthy controls.
Diet, growth, nutritional status and predictors of severity of feeding difficulties in autistic children with co-occurring pediatric feeding disorder.
Early Hum Dev
December 2024
Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Paediatric Gastroenterology, Nutrition, Hepatology and Liver Transplantation, Khoo Teck Puat - National University Children's Medical Institute, National University Hospital, National University Health System, Singapore.
Background: Feeding difficulties are commonly reported in autistic children. However, there is limited data on the presentation, severity, and impact of feeding difficulties in autistic children in Asia.
Aims: To describe the dietary patterns, growth and nutritional status of autistic children with pediatric feeding disorder (PFD), and identify factors associated with more severe feeding difficulties.
The use of abstract animations and a graphical body image for assessing pain outcomes among adults with sickle cell disease.
J Pain
October 2024
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Painimation, a novel digital pain assessment tool, allows patients to communicate their pain quality, intensity, and location using abstract animations (painimations) and a paintable body image. This study determined the construct validity of painimations and body image measures by testing correlations with validated pain outcomes in adults with sickle cell disease (SCD). Analyses used baseline data from a multisite randomized trial of 359 adults with SCD and chronic pain.
View Article and Find Full Text PDFIltamiocel Autologous Cell Therapy for the Treatment of Female Stress Urinary Incontinence: A Double-Blind, Randomized, Stratified, Placebo-Controlled Trial.
Neurourol Urodyn
November 2024
Corewell Health System, Oakland University William Beaumont School of Medicine, Rochester, Minnesota, USA.
Article Synopsis
- - The study evaluated the safety and effectiveness of iltamiocel, an autologous muscle cell therapy, for treating stress urinary incontinence (SUI) in women, comparing it to a placebo group.
- - Results showed no significant difference in the overall reduction of stress incontinence episodes between groups, but iltamiocel was more effective in women with previous SUI surgeries, indicating potential benefits for this specific population.
- - While the primary endpoint was not achieved, iltamiocel therapy was deemed safe, suggesting further research is needed for women with prior SUI surgery who lack effective treatment options.
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