Postoperative blood salvage reduces the risk of allogenic transfusion in patients undergoing elective total joint arthroplasty. We measured the concentrations of coagulation parameters after autotransfusion of unwashed shed blood in 22 patients having elective joint arthroplasty and compared them with patients without retransfusion. Twenty-two patients with a total hip or knee arthroplasty received a mean of 611.4 mL unwashed but filtered shed blood. No complications were observed during or after the reinfusion of salvaged blood. Levels of D-dimer and fibrinogen increased significantly over time after retransfusion (P < .0001). Comparison of the autotransfused group with the 25 patients without reinfused shed blood showed no significant difference in fibrinogen concentration between the 2 groups in the postoperative course but a significant difference with increased D-dimer concentrations in the autotransfused group (P < .001).
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http://dx.doi.org/10.1016/j.arth.2005.04.013 | DOI Listing |
Infect Drug Resist
January 2025
Department of Thoracic Surgery, The Second People's Hospital of Liaocheng, Linqing, Shandong, 252600, People's Republic of China.
Objective: This study aimed to investigate the levels of coagulation parameters in elderly patients with severe pneumonia and analyse their correlation with disease severity and prognosis.
Methods: A retrospective study was conducted on 207 elderly patients (aged ≥60 years) with severe pneumonia admitted to our hospital between January 2022 and December 2023. Demographic data, clinical characteristics and coagulation parameters, including prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time and fibrinogen (FIB), were collected.
Front Surg
January 2025
Department of Knee Joint Surgery, Xi'an Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Aims: This study compared the hemostatic effects and complications of oxidized regenerated cellulose (ORC) and topical TXA in total knee arthroplasty (TKA), thus providing a reference for the use of ORC as an alternative hemostatic agent to TXA in TKA.
Methods: A total of 105 patients were included in this study and randomized into blank control, ORC, and TXA groups. The primary outcomes were total blood loss, hemoglobin drop (Hb drop), transfusion rates, and incidence of thrombosis.
Thromb Haemost
January 2025
St Joseph's Hospital, Hamilton, Canada.
A DOAC concentration threshold above which an impact on surgical hemostasis starts to occur is unknown. Thrombin generation assays (TGAs) provide a measure of the coagulation phenotype. This study aimed to determine whether preoperative TGA parameters are associated with postoperative bleeding, and whether this is partly due to residual DOAC levels.
View Article and Find Full Text PDFHamostaseologie
January 2025
Department of Anaesthesiology and Intensive Care Medicine, Husum Hospital, Husum, Schleswig-Holstein, Germany.
Objectives: Trauma-induced coagulopathy (TIC) is common in severely injured patients and is associated with significant morbidity and mortality.
Method: The association of two parameters of blood gas analysis (hemoglobin [Hb], base excess [BE]) with standard coagulation tests (SCTs) and rotational thrombelastometry (ROTEM) using the database of the TraumaRegister DGU between 2015 and 2022 was studied. In a stepwise approach, the occurrence of a TIC, the correlations between Hb/BE levels and SCT, as well as ROTEM were calculated respectively.
Front Pharmacol
January 2025
Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Background: Radical cystectomy constitutes the standard therapeutic approach for high-risk urothelial carcinomas of the bladder. Contemporary guidelines advise urologists to discontinue anticoagulation therapy during the perioperative period to mitigate the risk of significant intraoperative or postoperative hemorrhage. Nevertheless, in elderly patients with a history of coronary artery disease, the cessation of anticoagulant medication elevates the risk of acute myocardial infarction, thereby posing a substantial threat to their survival.
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