Background: Despite that the role of inflammatory cells in chronic inflammatory reactions of pulpal origin (CIRPOs) has been extensively studied, function of the HLA-DR+ cells (HLA-DR+ Cs) is poorly understood. The aim of this study was to quantify their number and clarify their role in these lesions.
Methods: We studied 11 CIRPOs immunostained with an anti-HLA-DR class II monoclonal antibody and the number and location of the HLA-DR+ Cs quantified. CIRPOs were divided in periapical granulomas (PGs), epithelized granulomas (EGs) and periapical cysts (PCs).
Results: HLA-DR+ Cs were observed within epithelium, inflammatory infiltrate and close to blood vessels. In PGs, they account for 19-256 cells/mm2, in EGs they were 20-494 cells/mm2 and in PCs quantification numbered 39-316 cells/mm2.
Conclusions: Our results suggest that HLA-DR+ Cs present antigens to lymphocytes, collaborating in initiation, regulation, development and perpetuation of CIRPOs. Also, these results suggest that these cells have an active role during initiation of epithelial proliferation in PGs and that they are partially responsible for cystic transformation from EGs to periapical cysts. They may also play an active role in bone resorption.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.arcmed.2005.10.013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Immunoexpression of the HLA-DR class II molecule in cells from inflamed dental pulp.
Arch Med Res
May 2006
Laboratory of Immunology, División de Estudios de Posgrado e Investigación, Facultad de Odontología, UNAM, México, DF, México.
Background: Despite that the role of inflammatory cells in chronic inflammatory reactions of pulpal origin (CIRPOs) has been extensively studied, function of the HLA-DR+ cells (HLA-DR+ Cs) is poorly understood. The aim of this study was to quantify their number and clarify their role in these lesions.
Methods: We studied 11 CIRPOs immunostained with an anti-HLA-DR class II monoclonal antibody and the number and location of the HLA-DR+ Cs quantified.
Immunohistochemical analysis of CD1a-labeled Langerhans cells in human dental periapical inflammatory lesions--correlation with inflammatory cells and epithelial cells.
Oral Dis
November 2001
Division of Maxillofacial and Plastic Surgery, Department of Oro-Maxillofacial Surgical Science, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Objective: Distribution and density of CD1a-labeled Langerhans cells (LCs) were examined in human dental periapical inflammatory lesions, and compared with inflammatory cell infiltration or epithelial cell proliferation.
Materials And Methods: Eighty three periapical lesions (26 apical granulomas (AGs), 8 epitheliated granulomas (EGs), 34 radicular cysts (RCs), 15 residual radicular cysts (RRCs)) were collected. As control, specimens of periodontal ligaments including Malassez epithelial rests were curetted from 21 teeth.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!