Administration of antibody to the lung protects mice against pneumonic plague.

Infect Immun

Defence Science and Technology Laboratory, Porton Down, Wiltshire SP4 OJQ, United Kingdom.

Published: May 2006

Intratracheal delivery of aerosolized monoclonal antibodies with specificity for Yersinia pestis LcrV and F1 antigens protected mice in a model of pneumonic plague. These data support the utility of inhaled antibodies as a fast-acting postexposure treatment for plague.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459704PMC
http://dx.doi.org/10.1128/IAI.74.5.3068-3070.2006DOI Listing

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