Synthesis and photocytotoxic activity of new chlorin-polyamine conjugates.

Bioorg Med Chem Lett

Université de Limoges, Laboratoire de Chimie des Substances Naturelles, 123 Avenue Albert Thomas, F-87060 Limoges, France.

Published: June 2006

This paper reports the synthesis of new chlorin-polyamine conjugates designed to improve the targeting of cancer cells. Photocytotoxic activity of these photosensitizers was tested against human chronic myelogenous leukemia cells (K562) and compared to the effects of Photofrin II and chlorin e6.

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http://dx.doi.org/10.1016/j.bmcl.2006.03.044DOI Listing

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