We report the design, semisynthesis, and biological activity of a series of fredericamycin (1) derivatives. Within this series compound 1e combines low nanomolar cytotoxic potency in vitro, increased tumor cell line selectivity, and in vivo activity in a human xenograft model.
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| http://dx.doi.org/10.1016/j.bmcl.2006.03.029 | DOI Listing |
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