AI Article Synopsis
- Boesenbergia rotunda derivatives, specifically 4-hydroxypanduratin A and panduratin A, effectively inhibit the dengue 2 virus NS3 protease with Ki values of 21 and 25 microM.
- Pinostrobin and cardamonin demonstrated non-competitive inhibition against the same protease.
- The structures of the six isolated compounds were determined using NMR and GCMS spectroscopy techniques.
Article Abstract
Boesenbergia rotunda (L.) cyclohexenyl chalcone derivatives, 4-hydroxypanduratin A and panduratin A, showed good competitive inhibitory activities towards dengue 2 virus NS3 protease with the Ki values of 21 and 25 microM, respectively, whilst those of pinostrobin and cardamonin were observed to be non-competitive. NMR and GCMS spectroscopic data formed the basis of assignment of structures of the six compounds isolated.
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| http://dx.doi.org/10.1016/j.bmcl.2005.12.075 | DOI Listing |
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