AI Article Synopsis
- Nucleic acid amplification testing (NAAT) is effective for screening blood donors for West Nile virus (WNV) but hasn't been thoroughly studied in symptomatic patients.
- In a study of 276 WNV cases, both NAAT and WNV-specific immunoglobulin M testing were performed; NAAT detected 45% of cases, while serology detected 58%, with a combined approach detecting 94.2%.
- NAAT testing is particularly beneficial within the first 8 days of symptom onset, as early viremia is common in WNV infections, leading to improved diagnostic results.
Article Abstract
Although nucleic acid amplification testing (NAAT) for West Nile virus (WNV) is useful in screening blood donors, such methods have not been studied in symptomatic patients. For diagnosis of WNV infection, 1.0 mL of plasma was tested by NAAT, and WNV-specific immunoglobulin M was assayed. Of 276 WNV cases, 191 were tested by both serology and NAAT. Of these, 86 (45.0%), 111 (58.1%), and 180 (94.2%) were detected by NAAT, serology, and combined NAAT and serology, respectively. NAAT-based screening was most useful within 8 days of the onset of symptoms. Viremia is common in early symptomatic WNV infection, and NAAT enhances diagnostic yield.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1086/503577 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!