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Alemtuzumab as consolidation after a response to fludarabine is effective in purging residual disease in patients with chronic lymphocytic leukemia. | LitMetric

AI Article Synopsis

  • Alemtuzumab treatment improved response rates in chronic lymphocytic leukemia (CLL) patients, achieving a complete response rate increase from 35% to 79.4% after consolidation therapy, with 56% reaching minimal residual disease negativity.* -
  • The study involved 34 patients under 65 who received alemtuzumab injections for 6 weeks, and subsequent PBSC collection was successful in 92% of cases, facilitating further transplantation.* -
  • While most patients tolerated the treatment well, common side effects included injection-site reactions and fever, with some experiencing cytomegalovirus reactivation, effectively treated with ganciclovir.*

Article Abstract

Purpose: Treatment with alemtuzumab has resulted in negative responses for minimal residual disease (MRD) in patients with chronic lymphocytic leukemia (CLL). In a prior analysis we demonstrated that it is possible to achieved MRD negativity, as assessed by polyclonality of immunoglobulin heavy chain after consolidation with alemtuzumab. This phase II study evaluated 34 patients with CLL who received alemtuzumab consolidation in an effort to improve the quality of their response to fludarabine-based induction. Subsequent peripheral blood stem-cell (PBSC) collection and transplantation, tolerability, and pharmacokinetics also were assessed.

Patients And Methods: Thirty-four patients younger than 65 years who had a clinical response to fludarabine-based induction therapy received alemtuzumab 10 mg subcutaneously three times per week for 6 weeks. PBSCs were collected after mobilization with cytarabine and granulocyte colony-stimulating factor. Blood samples for pharmacokinetics study were taken between days 1 and 31.

Results: The complete response rate improved from 35% after fludarabine induction to 79.4% after alemtuzumab consolidation, including 19 patients (56%) who achieved MRD negativity. The most common adverse events were injection-site reactions and fever. Cytomegalovirus reactivation occurred in 18 patients, all of whom were successfully treated with oral ganciclovir. PBSC collection was successful in 24 (92%) of 26 patients, and 18 patients underwent autologous PBSC transplantation. Alemtuzumab plasma concentrations increased gradually during the first 2 weeks and accumulated more rapidly thereafter.

Conclusion: Subcutaneously administered alemtuzumab was effective, safe, and well tolerated as consolidation therapy in patients with CLL who responded to fludarabine induction therapy. Subsequent PBSCT was feasible thereafter.

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Source
http://dx.doi.org/10.1200/JCO.2005.04.6037DOI Listing

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