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New developments in lung function measurements in rodents. | LitMetric

AI Article Synopsis

  • There are both invasive and noninvasive tests for measuring lung function in rodents, with noninvasive midexpiratory flow (EF50) being useful for detecting bronchoconstriction in multiple animals.
  • A new technique allows for precise lung function monitoring in spontaneously breathing, intubated mice, using established measurements like airway resistance and dynamic compliance.
  • The combination of this new invasive method with an optimized inhalation technique enables sensitive detection of allergic responses in mice, demonstrating its effectiveness for both screening and chronic monitoring of respiratory function.

Article Abstract

There are invasive and noninvasive pulmonary function tests available which are sensitive in detecting bronchoconstriction in rodents. Noninvasively measured midexpiratory flow (EF50) has been shown to be an appropriate parameter to monitor bronchoconstriction in a large number of animals, e.g. for screening purposes. Recently, a novel technique for repetitive lung function measurements in orotracheally intubated, spontaneously breathing mice has been established. Bronchoconstriction is assessed by the "gold standard" parameters airway resistance and dynamic compliance in response to aerosolized methacholine or allergens in anesthetized mice. This measurement technique has been combined with an inhalation technique which has been optimized to allow simultaneous lung function measurement in intubated animals and to obtain high aerosol concentrations. A feedback dose control system has been developed to administer a defined and constant aerosol dose to each individual animal. Using this system a prominent early allergic response and late airway hyperresponsiveness could be demonstrated in intubated mice challenged with Aspergillus fumigatus allergen. We conclude: The noninvasive EF50 method seems particularly appropriate for measurements of respiratory function in large numbers of conscious mice in assembly line fashion. The invasive technology--newly established for the mouse--is more sensitive and specific since true airway resistance and dynamic compliance are determined and allows now the adequate detection of an early allergic response in the mouse and also repetitive measurements e.g. to assess the airway hyperresponsiveness in the same animal or for monitoring purposes in chronic models.

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Source
http://dx.doi.org/10.1016/j.etp.2006.02.011DOI Listing

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