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Daclizumab in the induction phase of immunosuppression in heart transplant recipients. | LitMetric
Objectives : Acute rejection episodes negatively effect both short-term survival and development of graft vasculopathy.Methods : We assessed the incidence and severity of acute rejection episodes under a new protocol using a monoclonal antibody daclizumab in the induction phase of immunosuppressive therapy. The study group B (26 patients) was given daclizumab (1 mg/kg), the control group A (25 patients) was treated without daclizumab. There was no significant difference between the two groups in the important data. A total of first 10 EMB in every patient was classified according to the ISHLT recommendation. We also analysed the incidence of infections.Results : During the first two months there was a significant lower incidence and/or severity of rejection episodes in the daclizumab group with p < or = 0.0016, 0.001 and 0.005 respectively.Conclusions : Induction therapy with daclizumab significantly reduces the incidence of acute rejection episodes during the first two posttransplant months in heart transplant recipients. It does not increase the risk of infection.
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