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The Adh adhesin domain is required for trimeric autotransporter Apa1-mediated Actinobacillus pleuropneumoniae adhesion, autoaggregation, biofilm formation and pathogenicity.
Vet Microbiol
May 2015
College of Veterinary Medicine, Jilin University, Xi'an Road 5333, Changchun, PR China. Electronic address:
Actinobacillus pleuropneumoniae is a causative agent of porcine pleuropneumonia, which is a highly contagious endemic disease of pigs. Adhesion is a critical first step in the infection process. Trimeric autotransporter adhesions (TAAs) have been identified as novel virulence factors; however, little is known on their roles in A.
View Article and Find Full Text PDFCardiac overexpression of catalase antagonizes ADH-associated contractile depression and stress signaling after acute ethanol exposure in murine myocytes.
J Appl Physiol (1985)
December 2005
Division of Pharmaceutical Sciences & Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071, USA.
Alcohol dehydrogenase (ADH), which oxidizes ethanol into acetaldehyde, exacerbates ethanol-induced cardiac depression, although the mechanism of action remains unclear. This study was designed to examine the impact of antioxidant catalase (CAT) on cardiac contractile response to ethanol and activation of stress signaling. ADH-CAT double transgenic mice were generated by crossing CAT and ADH lines.
View Article and Find Full Text PDFTransducing pathways involved in the control of NaCl reabsorption in the thick ascending limb of Henle's loop.
Kidney Int Suppl
April 1998
URA CNRS 1869, Département de Biologie Cellulaire et Moléculaire, CEA Saclay, France.
The thick ascending limb of Henle's loop (TAL) is involved in the urinary dilution/concentration process by actively reabsorbing NaCl through a complex mechanism. Some years ago, compelling evidence was provided that cAMP stimulates NaCl reabsorption through the activation of adenylyl cyclase by several hormones other than antidiuretic hormone (ADH). Synthesis of cyclic AMP is inhibited by prostaglandin E2 (PGE2) and arachidonic acid per se, via the pertussis toxin-sensitive protein Gi activation.
View Article and Find Full Text PDFAntidiuretic response in the urinary bladder of Xenopus laevis: presence of typical aggrephores and apical aggregates.
Biol Cell
September 1994
Département de Biologie Cellulaire et Moléculaire, Centre d'Etudes de Saclay, Gif-sur-Yvette, France.
The urinary bladder of the aquatic toad Xenopus laevis is known to exhibit a low permeability to water and a poor sensitivity to antidiuretic hormone. In order to precise the characteristics and the specific cellular mechanisms of this reduced hydro-osmotic response we used a sensitive volumetric technique to monitor net water flow and studied the correlation between the antidiuretic hormone (ADH)-induced net water flow and the fine ultrastructural appearance of the urinary bladder epithelium. Transmural net water flow was entirely dependent on the osmotic gradient across the preparation and not on the hydrostatic pressure difference.
View Article and Find Full Text PDFTransepithelial water movement in response to carbamazepine, chlorpropamide and demeclocycline in toad urinary bladder.
Br J Pharmacol
October 1991
Department of Medicine, School of Postgraduate Medicine and Biological Sciences, University of Keele, Hartshill, Stoke on Trent.
1. Osmotic water movement across toad isolated hemibladders was measured by a gravimetric method. 2.
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