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Maternal postpartum mental health negatively affects infants' health related quality of life.
J Affect Disord
January 2025
Department of Health Sciences, University Medical Center Groningen, University of Groningen, the Netherlands.
Objectives: To assess the association of early and late postpartum maternal mental health with infants' health related quality of life (HRQoL).
Methods: The study was embedded within the POST-UP trial (n = 1843). Infants' HRQoL was assessed with the Infant and Toddler Quality of Life Questionnaire Short Form-47 at ages 1 month (1 m), and 12 m.
Exploring childbirth experiences through a Salutogenic lens.
Midwifery
December 2024
School of Community Health and Midwifery, University of Central Lancashire, Preston, Lancashire PR1 2HE, UK. Electronic address:
Women's experiences of childbirth have generally been considered through a pathological lens. Wider sociological arguments associated with salutogenesis stress the need to depict health on a continuum to help understand what constitutes positive health as well as ill-health. Similarly, to fully understand women's experiences of childbirth, it needs to be explored on a continuum, considering salutogenic and pathogenic factors.
View Article and Find Full Text PDFDual inhibition of MAPK/ERK and BMP signaling induces entorhinal-like identity in mouse ESC-derived pallial progenitors.
Stem Cell Reports
December 2024
Laboratorio di Biologia, Scuola Normale Superiore, 56126 Pisa, Italy; Istituto di Biofisica, Consiglio Nazionale delle Ricerche, 56124 Pisa, Italy. Electronic address:
The mechanisms that determine distinct embryonic pallial identities remain elusive. The central role of Wnt signaling in directing dorsal telencephalic progenitors to the isocortex or hippocampus has been elucidated. Here, we show that timely inhibition of MAPK/ERK and BMP signaling in neuralized mouse embryonic stem cells (ESCs) specifies a cell identity characteristic of the allocortex.
View Article and Find Full Text PDFAn Atypical Case of Neonatal Alloimmune Thrombocytopenia.
J Pediatr Hematol Oncol
January 2025
Departments of Laboratory Medicine.
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from maternal antibodies targeting fetal platelets during pregnancy, often causing hemorrhagic manifestations detectable antenatally or shortly after birth. We report an atypical form of FNAIT with delayed onset in a healthy, breastfed male infant who developed diffuse petechiae 2 weeks after birth due to severe thrombocytopenia. The mother was shown to be negative for the human platelet antigen-1a (HPA-1a) allele but had anti-HPA-1a IgG antibodies, while the father and newborn were HPA-1a positive, confirming the diagnosis.
View Article and Find Full Text PDFMaternal nutrition and offspring lung health: sex-specific pathway modulation in fibrosis, metabolism, and immunity.
Food Nutr Res
January 2025
Department of Gynaecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Background: Maternal nutrition profoundly influences offspring health, impacting both prenatal and early postnatal development. Previous studies have demonstrated that maternal dietary habits can affect key developmental pathways in the offsprings, including those related to lung function and disease susceptibility. However, the sex-specific impact of a maternal high-salt diet (HSD) on offspring lung injury remains poorly understood.
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