AI Article Synopsis
- Meiotic chromosomes in many organisms cluster at their telomeres to create a "bouquet" structure, which is crucial for homologous chromosome pairing during meiosis.
- Researchers found that in fission yeast, bouquet formation is influenced by mating pheromone signaling, prompting the search for genes involved in this process.
- Two proteins, Bqt1 and Bqt2, were identified as essential connectors between telomeres and the spindle-pole body, with the two working together to link telomere protein Rap1 and SPB protein Sad1.
Article Abstract
In many organisms, meiotic chromosomes are bundled at their telomeres to form a "bouquet" arrangement. The bouquet formation plays an important role in homologous chromosome pairing and therefore progression of meiosis. As meiotic telomere clustering occurs in response to mating pheromone signaling in fission yeast, we looked for factors essential for bouquet formation among genes induced under mating pheromone signaling. This genome-wide search identified two proteins, Bqt1 and Bqt2, that connect telomeres to the spindle-pole body (SPB; the centrosome equivalent in fungi). Neither Bqt1 nor Bqt2 alone functions as a connector, but together the two proteins form a bridge between Rap1 (a telomere protein) and Sad1 (an SPB protein). Significantly, when both Bqt1 and Bqt2 are ectopically expressed in mitotic cells, they also form a bridge between Rap1 and Sad1. Thus, a complex including Bqt1 and Bqt2 is essential for connecting telomeres to the SPB.
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| http://dx.doi.org/10.1016/j.cell.2006.01.048 | DOI Listing |
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