AI Article Synopsis
- Angiogenesis plays a key role in follicular development, with each follicle having its own independent regulatory mechanisms for its blood vessel formation.
- The review discusses methods to monitor angiogenesis in follicles, examines various pro- and anti-angiogenic factors that affect this process, and highlights the role of antagonists in studying these factors.
- Inhibiting specific components like VEGF and angiopoietins can disrupt follicular development and impede ovulation.
Article Abstract
Angiogenesis is associated with follicular development and is regulated independently within each follicle potentially making the functioning of its vasculature critically important in determining its fate. This review examines the various ways in which follicular angiogenesis may be monitored, describes the follicular localisation and changes in pro- and anti-angiogenic factors that may regulate the process and how antagonists may be used to elucidate their physiological role in vivo. Thus, inhibition of vascular endothelial growth factor (VEGF), VEGF receptor-2, vascular endothelial cell cadherin or interference with the angiopoietin system can inhibit follicular development or prevent ovulation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459163 | PMC |
| http://dx.doi.org/10.1186/1477-7827-4-18 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!